Evidence map›Paper›PMID 21217678›Full record

ArticleNature medicine2011

Catapulting clopidogrel pharmacogenomics forward.

Eric J Topol, Nicholas J Schork

Registry-linked trialAbstract readNewsComment
PubMed Publisher
In one paragraph

Article in Nature medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01611545 (Can Pharmacogenomic Testing Improve Response and Avoid Adverse Effects With Clopidogrel Therapy? A Biospecimen Bank for Genetic and Genomic Investigation of Clopidogrel.), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01611545 completednot on this mapstarted 2012, after this paper: background citation

Can Pharmacogenomic Testing Improve Response and Avoid Adverse Effects With Clopidogrel Therapy? A Biospecimen Bank for Genetic and Genomic Investigation of Clopidogrel.

TypeobservationalSponsorAvera McKennan Hospital & University Health CenterRan2012 to 2015Enrolled130ConditionsPharmacogenomics and Cardiovascular EventsArmsPharmacogenomics
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Eric J Topol
Nicholas J Schork

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amino Acid SubstitutionAryldialkylphosphataseAspirinBlood PlateletsClopidogrelDrug Therapy, CombinationHumansPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsStentsThrombosisTiclopidineAryldialkylphosphataseAspirinClopidogrelPlatelet Aggregation InhibitorsPON1 protein, humanPurinergic P2Y Receptor AntagonistsTiclopidine

Identifiers

PMID21217678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.