ArticleThe EMBO journal2011
Retinoblastoma protein is essential for early meiotic events in Arabidopsis.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Developmental cues are encoded by the combinatorial phosphorylation of Arabidopsis RETINOBLASTOMA-RELATED protein RBR1.The EMBO journal · 2024Article
- RETINOBLASTOMA RELATED 1 switches mitosis to meiosis in rice.Plant communications · 2024Article
- The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development.Communications biology · 2023Article
- Sporophytic control of pollen meiotic progression is mediated by tapetum expression of ABORTED MICROSPORES.Journal of experimental botany · 2022Article
- Direct Regulation of DNA Repair by E2F and RB in Mammals and Plants: Core Function or Convergent Evolution?Cancers · 2021Review
- Caught in the Act: Live-Cell Imaging of Plant Meiosis.Frontiers in plant science · 2021Review
- The Formation of Bivalents and the Control of Plant Meiotic Recombination.Frontiers in plant science · 2021Review
- Roles of plant retinoblastoma protein: cell cycle and beyond.The EMBO journal · 2020Review
- The evolution and functional divergence of the histone H2B family in plants.PLoS genetics · 2020Article
- MeioCapture: an efficient method for staging and isolation of meiocytes in the prophase I sub-stages of meiosis in wheat.BMC plant biology · 2018Article
- RETRACTED: Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators.PLoS genetics · 2018Article
- The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions inThe EMBO journal · 2017Article
- Article
- Analysis of the Relationships between DNA Double-Strand Breaks, Synaptonemal Complex and Crossovers Using the Atfas1-4 Mutant.PLoS genetics · 2015Article
- pRb-E2F signaling in life of mesenchymal stem cells: Cell cycle, cell fate, and cell differentiation.Genes & diseases · 2014Review
- Defects in a new class of sulfate/anion transporter link sulfur acclimation responses to intracellular glutathione levels and cell cycle control.Plant physiology · 2014Article
- SUMO E3 ligase AtMMS21 is required for normal meiosis and gametophyte development in Arabidopsis.BMC plant biology · 2014Article
- CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The synaptonemal complex protein ZYP1 is required for imposition of meiotic crossovers in barley.The Plant cell · 2014Article
- Transcriptomic landscape of prophase I sunflower male meiocytes.Frontiers in plant science · 2014Article
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6 authors at 3 institutions in 2 countries.
Funding
Abstract
We have analysed the role of RBR (retinoblastoma related), the Arabidopsis homologue of the tumour suppressor Retinoblastoma protein (pRb), during meiosis. We characterise the rbr-2 mutation, which causes a loss of RBR in male meiocytes. The rbr-2 plants exhibit strongly reduced fertility, while vegetative growth is generally unaffected. The reduced fertility is due to a meiotic defect that results in reduced chiasma formation and subsequent errors in chromosome disjunction. Immunolocalisation studies in wild-type meiocytes reveal that RBR is recruited as foci to the chromosomes during early prophase I in a DNA double-strand-break-dependent manner. In the absence of RBR, expression of several meiotic genes is reduced. The localisation of the recombinases AtRAD51 and AtDMC1 is normal. However, localisation of the MutS homologue AtMSH4 is compromised. Additionally, polymerisation of the synaptonemal complex protein AtZYP1 is abnormal. Together, these data indicate that loss of RBR during meiosis results in a reduction of crossover formation and an associated failure in chromosome synapsis. Our results indicate that RBR has an important role in meiosis affecting different aspects of this complex process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.