ArticleAnnals of surgery2011
Angiogenesis in wounds treated by microdeformational wound therapy.
Article in Annals of surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 203 citations in OpenAlex.
- Oncologic feasibility for negative pressure wound therapy application in surgical wounds: A meta-analysis.International wound journal · 2022Pooled it
- Indigenous Negative Pressure Wound Therapy: A Low-cost Equivalent Alternative to Conventional Vacuum-assisted Closure Therapy - A Prospective Randomized Open-blind Endpoint Study.Annals of African medicine · 2025Trial
- Effect of Negative Pressure Wound Therapy on Wound Complications Post-Pancreatectomy.The American surgeon · 2019Trial
- Phase II Randomized Trial of Negative-Pressure Wound Therapy to Decrease Surgical Site Infection in Patients Undergoing Laparotomy for Gastrointestinal, Pancreatic, and Peritoneal Surface Malignancies.Journal of the American College of Surgeons · 2017Trial
- Trial
- Clinical outcome and microvascular blood flow in VAC® - and Sorbalgon® -treated peri-vascular infected wounds in the groin after vascular surgery - an early interim analysis.International wound journal · 2013Trial
- Effects of the Foam Massage Roller on VEGF-A and FGF-2 Blood Levels in Young Men.In vivo (Athens, Greece)Trial
- Comparative Efficacy of Dynamic and Contact Cooling With the Fifth-generation Pulsed Dye Laser for Breast Surgical Scars in Cancer Survivors.Plastic and reconstructive surgery. Global open · 2026Article
- Negative pressure mechanical signal increases the phosphorylation of eNOS Ser1177 by upregulating HSP90 expression to promote wound angiogenesis.Journal of advanced research · 2026Article
- Negative-Pressure Induces Epithelial-Mesenchymal Transition via Thrombospondin-1 Upregulation in Intact Diabetic Skin.International wound journal · 2026Article
- Simplified Negative Pressure Wound Therapy: A Cost-Effective Solution for Wound Management.Journal of orthopaedic case reports · 2026Article
- Successful treatment of gastrobronchial fistula following laparoscopic sleeve gastrectomy: A case report and review of literature.World journal of gastrointestinal surgery · 2026Article
- An Ex Vivo Study Measuring the Effects of Circumferential and Near-Circumferential Closed Incisional Negative Pressure Wound Therapy Dressings on a Porcine Model.Hawai'i journal of health & social welfare · 2026Article
- [Clinical effect of tibial transverse transport technique combined with continuous low negative pressure wound therapy in the treatment of Wagner grade Ⅲ to Ⅴ chronic diabetic foot ulcers].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- Tailored Negative Pressure Wound Therapy with instillation in diabetic, hypertensive, and obese patients-when guideline treatment is not enough: a case series and a proposal for the ANSWER score.World journal of emergency surgery : WJES · 2025Article
- The Use of Integra Dermal Regeneration Template in Exposed Bone Reconstruction: A Case Report with Systematic Literature Review.Journal of clinical medicine · 2025Review
- Finite element and preclinical analysis of tissue response to negative pressure wound therapy with a felted foam containing 10 mm through holes.Frontiers in bioengineering and biotechnology · 2025Article
- Revisiting negative pressure wound therapy from a mechanobiological perspective supported by clinical and pathological data.International wound journal · 2024Review
- The Impact of EndoVAC in Addressing Post-Esophagectomy Anastomotic Leak in Esophageal Cancer Management.Journal of clinical medicine · 2024Review
- The role of vasculature and angiogenesis in respiratory diseases.Angiogenesis · 2024Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundMechanical forces play an important role in tissue neovascularization and are a constituent part of modern wound therapies. The mechanisms by which vacuum assisted closure (VAC) modulates wound angiogenesis are still largely unknown.
objectiveTo investigate how VAC treatment affects wound hypoxia and related profiles of angiogenic factors as well as to identify the anatomical characteristics of the resultant, newly formed vessels.
methodsWound neovascularization was evaluated by morphometric analysis of CD31-stained wound cross-sections as well as by corrosion casting analysis. Wound hypoxia and mRNA expression of HIF-1α and associated angiogenic factors were evaluated by pimonidazole hydrochloride staining and quantitative reverse transcription-polymerase chain reaction (RT-PCR), respectively. Vascular endothelial growth factor (VEGF) protein levels were determined by western blot analysis.
resultsVAC-treated wounds were characterized by the formation of elongated vessels aligned in parallel and consistent with physiological function, compared to occlusive dressing control wounds that showed formation of tortuous, disoriented vessels. Moreover, VAC-treated wounds displayed a well-oxygenated wound bed, with hypoxia limited to the direct proximity of the VAC-foam interface, where higher VEGF levels were found. By contrast, occlusive dressing control wounds showed generalized hypoxia, with associated accumulation of HIF-1α and related angiogenic factors.
conclusionsThe combination of established gradients of hypoxia and VEGF expression along with mechanical forces exerted by VAC therapy was associated with the formation of more physiological blood vessels compared to occlusive dressing control wounds. These morphological changes are likely a necessary condition for better wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.