ArticleThe Journal of trauma2011
Multiple levels of degradation diminish hemostatic potential of thawed plasma.
Article in The Journal of trauma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series.Animals : an open access journal from MDPI · 2023Article
- Targeting repair of the vascular endothelium and glycocalyx after traumatic injury with plasma and platelet resuscitation.Matrix biology plus · 2022Review
- Age of thawed plasma does not affect clinical outcomes or biomarker expression in patients receiving prehospital thawed plasma: a PAMPer secondary analysis.Trauma surgery & acute care open · 2021Article
- Prolonged (post-thaw) shelf life of -80°C frozen AB apheresis plasma.Transfusion · 2020Article
- Identification of Fibrinogen as a Key Anti-Apoptotic Factor in Human Fresh Frozen Plasma for Protecting Endothelial Cells In Vitro.Shock (Augusta, Ga.) · 2020Article
- Lyophilized plasma attenuates vascular permeability, inflammation and lung injury in hemorrhagic shock.PloS one · 2018Article
- Redox Status, Procoagulant Activity, and Metabolome of Fresh Frozen Plasma in Glucose 6-Phosphate Dehydrogenase Deficiency.Frontiers in medicine · 2018Article
- 14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis.The Journal of surgical research · 2017Article
- Microparticles variability in fresh frozen plasma: preparation protocol and storage time effects.Blood transfusion = Trasfusione del sangue · 2016Article
- Microvesicle phenotypes are associated with transfusion requirements and mortality in subjects with severe injuries.Journal of extracellular vesicles · 2015Article
- Cellular microparticle and thrombogram phenotypes in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study: correlation with coagulopathy.Thrombosis research · 2014Observational
- Transfusion-Related Acute Lung Injury: The Work of DAMPs.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2013Article
- Cell-derived microparticles in stored blood products: innocent-bystanders or effective mediators of post-transfusion reactions?Blood transfusion = Trasfusione del sangue · 2012Review
- Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage.The Journal of trauma · 2011Article
- Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma.Thrombosis research · 2011Article
- Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.Shock (Augusta, Ga.) · 2011Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSevere bleeding after injury requires transfusion of blood products, including fresh frozen plasma (FFP). Many centers are keeping thawed plasma (TP) ready for massively transfused patients. According to the American Association of Blood Banks Standards, TP is approved for transfusion up to 5 days after thawing, when stored at 1°C to 6°C. However, there are no clinical data analyzing the effects of the approved 5-day storage on plasma. We hypothesize that the hemostatic potential (HP) of freshly thawed (FFP-0) was superior to plasma stored for 5 days (FFP-5).
methodsFFP from 30 single donors were thawed at 37°C and kept at 1°C to 6°C for 5 days. HP was evaluated at day 0 and 5 by measuring kinetics of thrombin generation (TG), kinetics of clot formation by thromboelastography, clotting factors and inhibitors, and cell-derived microparticles (MPs) by flow cytometry.
resultsWhen comparing FFP-5 to FFP-0, FFP-5 exhibited only 40% of the potential of FFP-0 for TG (6.2 nM/min vs. 14.3 nM/min, p<0.0001), a slower clotting response via thromboelastography (reaction time: 4.3 minutes vs. 3.2 minutes, p<0.0001) and a longer delay in reaching maximum thrombus generation (5.7 minutes vs. 4.6 minutes, p<0.01). Diminished HP was accompanied by a significant decline in multiple coagulation proteins, including FV, VII, VIII, von Willebrand factor, and free Protein S, by up to 30%, and a decrease of 50% in MP counts.
conclusionThe HP and clot forming ability of TP significantly declined with storage. Hence, freshly TP may have a greater ability to restore hemostasis and correct coagulopathy compared with FFP-5. The clinical consequences for transfused patients deserve further exploration.
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