ArticleThe Journal of cell biology1990
Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 174 citations in OpenAlex.
- Chiral inversion mutagenesis identifies geometrically constrained residues within self-associating low-complexity domains.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Chiral inversion mutagenesis identifies geometrically constrained residues within self-associating low-complexity domains.bioRxiv : the preprint server for biology · 2025Article
- Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing.Molecular biology of the cell · 2023Article
- Mutations linked to neurological disease enhance self-association of low-complexity protein sequences.Science (New York, N.Y.) · 2022Article
- A review and analysis of the clinical literature on Charcot-Marie-Tooth disease caused by mutations in neurofilament protein L.Cytoskeleton (Hoboken, N.J.) · 2021Review
- Transiently structured head domains control intermediate filament assembly.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cytoskeleton as a Target of Quinolinic Acid Neurotoxicity: Insight from Animal Models.Molecular neurobiology · 2018Review
- Vitamin DNeuromolecular medicine · 2017Article
- Assembly properties of lamprey neurofilament subunits and their expression after spinal cord transection.The Journal of comparative neurology · 2011Article
- Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration.Molecular psychiatry · 2010Article
- A novel recessive Nefl mutation causes a severe, early-onset axonal neuropathy.Annals of neurology · 2009Article
- Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration.Molecular neurobiology · 2008Review
- Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments.Experimental cell research · 2007Review
- NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth.The Journal of cell biology · 2003Article
- The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate.The Journal of cell biology · 2003Article
- An intact intermediate filament network is required for collateral sprouting of small diameter nerve fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Untranslated element in neurofilament mRNA has neuropathic effect on motor neurons of transgenic mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.The Journal of cell biology · 2002Article
- Bcl-2 overexpression does not protect neurons from mutant neurofilament-mediated motor neuron degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have generated a set of amino- and carboxy-terminal deletions of the NF-L neurofilament gene and determined the assembly properties of the encoded subunits after coexpression with vimentin or wild-type NF-L. NF-L molecules missing greater than 30% (31 amino acids of the head) or 90% (128 amino acids of the tail) failed to incorporate into intermediate filament networks. Carboxy-terminal deletions into the rod domain yield dominant mutants that disrupt arrays assembled from wild-type subunits, even when present at levels of approximately 2% of the wild-type subunits. Even mutants retaining 55% of the tail (61 amino acids) disrupt normal arrays when accumulated above approximately 10% of wild-type subunits. Since deletion of greater than 90% of the head domain produces "recessive" assembly incompetent subunits that do not affect wild-type filament arrays, whereas smaller deletions yield efficient network disruption, we conclude that some sequence(s) in the head domain (within residues 31-87) are required for the earliest steps in filament assembly. Insertional mutagenesis in the nonhelical spacer region within the rod domain reveals that as many as eight additional amino acids can be tolerated without disrupting assembly competence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.