ArticleCell cycle (Georgetown, Tex.)2011
Centrosomal localization of cyclins E and A: structural similarities and functional differences.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Cellular polyploidy in organ homeostasis and regeneration.Protein & cell · 2023Article
- An updated view on the centrosome as a cell cycle regulator.Cell division · 2022Review
- Quantitative Systems Biology to decipher design principles of a dynamic cell cycle network: the "Maximum Allowable mammalian Trade-Off-Weight" (MAmTOW).NPJ systems biology and applications · 2017Review
- Article
- CentrosomeDB: a new generation of the centrosomal proteins database for Human and Drosophila melanogaster.Nucleic acids research · 2014Article
- Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1.Cell cycle (Georgetown, Tex.) · 2013Article
- An integrated view of cyclin E function and regulation.Cell cycle (Georgetown, Tex.) · 2012Article
- Cyclin-specific docking motifs promote phosphorylation of yeast signaling proteins by G1/S Cdk complexes.Current biology : CB · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent identification of the modular CLS motifs responsible for cyclins A and E localization on centrosomes has revealed a tight linkage between the nuclear and centrosomal cycles. These G1/S cyclins must localize on the centrosome in order for DNA replication to occur in the nucleus, whereas essential DNA replication factors also function on the centrosome to prevent centrosome overduplication. Both events are dependent on the presence of an intact CLS within each cyclin. Here we compare the cyclins A and E CLSs at the structural and functional levels and identify a new cyclin A CLS mutant that disrupts all CLS functions and reduces the affinity of cyclin A for Cdk2. Analysis of interactions of the CLS motif within the cyclin molecules highlights the importance of the cyclin CBOX1 region for Cdk2 binding.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.