ArticleThe Journal of antimicrobial chemotherapy2011
Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures.
Article in The Journal of antimicrobial chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cycling empirical antibiotic therapy in hospitals: meta-analysis and models.PLoS pathogens · 2014Pooled it
- Ready-to-Eat Sandwich Microbiota: Diversity, Antibiotic Resistance, and Strategies to Enhance Food Safety.Foods (Basel, Switzerland) · 2026Review
- Multidrug-Resistant Bacteria: Their Mechanism of Action and Prophylaxis.BioMed research international · 2022Review
- Multidrug-Resistant Bacteria in the Community: An Update.Infectious disease clinics of North America · 2020Review
- ESKAPE Bacteria and Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolated from Wastewater and Process Water from German Poultry Slaughterhouses.Applied and environmental microbiology · 2020Article
- Microbial load and antibiotic resistance in raw beef preparations from northwest Spain.Food science & nutrition · 2020Article
- Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.Nature communications · 2018Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Impact on Public Health of the Spread of High-Level Resistance to Gentamicin and Vancomycin in Enterococci.Frontiers in microbiology · 2018Review
- Multidrug-Resistant Bacteria in the Community: Trends and Lessons Learned.Infectious disease clinics of North America · 2016Review
- The fitness costs of antibiotic resistance mutations.Evolutionary applications · 2015Review
- Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids.Nature communications · 2014Article
- Detecting rare gene transfer events in bacterial populations.Frontiers in microbiology · 2014Review
- Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis.The Journal of antimicrobial chemotherapy · 2013Article
- Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment.Environmental health perspectives · 2013Review
- Country-specific antibiotic use practices impact the human gut resistome.Genome research · 2013Article
- Proof of concept for eradication of vancomycin resistant Enterococcus faecium from broiler farms.Acta veterinaria Scandinavica · 2013Article
- Integrons: Vehicles and pathways for horizontal dissemination in bacteria.Mobile genetic elements · 2012Article
- Assessing the probability of detection of horizontal gene transfer events in bacterial populations.Frontiers in microbiology · 2012Article
- Vancomycin resistant enterococci in farm animals - occurrence and importance.Infection ecology & epidemiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo estimate the relative fitness differences between glycopeptide-resistant Enterococcus faecium (GREF) and glycopeptide-susceptible E. faecium (GSEF) from yearly surveillance data on the occurrence of GREF in Danish poultry farm environments.
methodsA population genetic model was adapted to retrospectively estimate the biological fitness cost of acquired resistance. Maximization of a likelihood function was used to predict the longitudinal persistence of acquired resistance.
resultsOur analysis suggests strong selection against GREF following the 1995 ban on the glycopeptide growth promoter avoparcin. However, parameterizing the model with two selection coefficients suggesting a reduced negative effect of the acquired resistance on bacterial fitness over time significantly improved the fit of the model. Our analyses suggest that the acquired glycopeptide resistance will persist for >25 years.
conclusionsAcquired resistance determinants in commensal E. faecium populations in Danish farm environments are likely to persist for decades, even in the absence of glycopeptide use.
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