ArticleInvestigative ophthalmology & visual science2011
Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration.eLife · 2023Article
- Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses.PLoS genetics · 2023Article
- A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish.Frontiers in cell and developmental biology · 2023Article
- Comparative analysis of transcriptional changes in zebrafishFrontiers in molecular neuroscience · 2023Article
- Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Zebrafish models of inherited retinal dystrophies.Journal of translational genetics and genomics · 2022Article
- Zebrafish Models of Photoreceptor Dysfunction and Degeneration.Biomolecules · 2021Review
- Her9/Hes4 is required for retinal photoreceptor development, maintenance, and survival.Scientific reports · 2020Article
- Capn5 Expression in the Healthy and Regenerating Zebrafish Retina.Investigative ophthalmology & visual science · 2018Article
- Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina.Journal of neuroinflammation · 2018Article
- Transcripts within rod photoreceptors of the Zebrafish retina.BMC genomics · 2018Article
- Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration.Frontiers in cell and developmental biology · 2018Article
- Identification and characterization of variants and a novel 4 bp deletion in the regulatory region ofMolecular genetics & genomic medicine · 2017Article
- Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish.Investigative ophthalmology & visual science · 2016Article
- Expression of the insulinoma-associated 1 (insm1) gene in Xenopus laevis tadpole retina and brain.Gene expression patterns : GEP · 2016Article
- Tracking the fate of her4 expressing cells in the regenerating retina using her4:Kaede zebrafish.Experimental eye research · 2016Article
- Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina.Scientific reports · 2016Article
- Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis.Developmental biology · 2015Article
- Keeping an eye on SOXC proteins.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Müller glia-derived neuronal progenitor cells.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeXOPS-mCFP transgenic zebrafish experience a continual cycle of rod photoreceptor development and degeneration throughout life, making them a useful model for investigating the molecular determinants of rod photoreceptor regeneration. The purpose of this study was to compare the gene expression profiles of wild-type and XOPS-mCFP retinas and identify genes that may contribute to the regeneration of the rods.
methodsAdult wild-type and XOPS-mCFP retinal mRNA was subjected to microarray analysis. Pathway analysis was used to identify biologically relevant processes that were significantly represented in the dataset. Expression changes were verified by RT-PCR. Selected genes were further examined during retinal development and in adult retinas by in situ hybridization and immunohistochemistry and in a transgenic fluorescent reporter line.
resultsMore than 600 genes displayed significant expression changes in XOPS-mCFP retinas compared with expression in wild-type controls. Many of the downregulated genes were associated with phototransduction, whereas upregulated genes were associated with several biological functions, including cell cycle, DNA replication and repair, and cell development and death. RT-PCR analysis of a subset of these genes confirmed the microarray
resultsThree transcription factors (sox11b, insm1a, and c-myb), displaying increased expression in XOPS-mCFP retinas, were also expressed throughout retinal development and in the persistently neurogenic ciliary marginal zone.
conclusionsThis study identified numerous gene expression changes in response to rod degeneration in zebrafish and further suggests a role for the transcriptional regulators sox11b, insm1a, and c-myb in both retinal development and rod photoreceptor regeneration.
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