ArticleThe Plant cell2011
The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 184 citations in OpenAlex.
- Glucose-TOR-PDCB signaling restricts cell-to-cell communication through callose deposition.Science advances · 2026Article
- Glucose-TOR Signaling Regulates Root Hair Elongation inPlants (Basel, Switzerland) · 2026Article
- A current view on the involvement of protein phosphatase PP2A subunits in the responses of plants to abiotic stress at the subcellular level.Plant cell reports · 2026Review
- TOR Signaling as a Central Integrator of Embryogenic Reprogramming During 2,4-D-Induced Somatic Embryogenesis.International journal of molecular sciences · 2026Review
- Decoding the growth-defense dialectic: TOR signaling and developmental genetics in maize.Journal of experimental botany · 2026Review
- Comparative Proteomic Analysis of Non-Bleached and Bleached Fragments of the HydrocoralBiology · 2025Article
- Differential gene expression of salt-tolerant alfalfa in response to salinity and inoculation by Ensifer meliloti.BMC plant biology · 2024Article
- What, where, and how: Regulation of translation and the translational landscape in plants.The Plant cell · 2024Review
- Transcriptional and post-translational regulation of plant autophagy.Journal of experimental botany · 2023Review
- Genome-wide association study of drought tolerance traits in sugar beet germplasms at the seedling stage.Frontiers in genetics · 2023Article
- TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development.Journal of experimental botany · 2022Review
- The plant TOR kinase tunes autophagy and meristem activity for nutrient stress-induced developmental plasticity.The Plant cell · 2022Article
- Sugar metabolism during pre- and post-fertilization events in plants under high temperature stress.Plant cell reports · 2022Review
- Genome-wide identification and expression analysis ofFrontiers in genetics · 2022Article
- Proteomic and metabolomic analysis of Nicotiana benthamiana under dark stress.FEBS open bio · 2022Article
- Dynamic Nutrient Signaling Networks in Plants.Annual review of cell and developmental biology · 2021Review
- Contributions of TOR Signaling on Photosynthesis.International journal of molecular sciences · 2021Review
- TOR coordinates nucleotide availability with ribosome biogenesis in plants.The Plant cell · 2021Article
- A Tour of TOR Complex Signaling in Plants.Trends in biochemical sciences · 2021Review
- The Protein Phosphatase PP2A Plays Multiple Roles in Plant Development by Regulation of Vesicle Traffic-Facts and Questions.International journal of molecular sciences · 2021Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tap42/α4, a regulatory subunit of protein phosphatase 2A, is a downstream effector of the target of rapamycin (TOR) protein kinase, which regulates cell growth in coordination with nutrient and environmental conditions in yeast and mammals. In this study, we characterized the functions and phosphatase regulation of plant Tap46. Depletion of Tap46 resulted in growth arrest and acute plant death with morphological markers of programmed cell death. Tap46 interacted with PP2A and PP2A-like phosphatases PP4 and PP6. Tap46 silencing modulated cellular PP2A activities in a time-dependent fashion similar to TOR silencing. Immunoprecipitated full-length and deletion forms of Arabidopsis thaliana TOR phosphorylated recombinant Tap46 protein in vitro, supporting a functional link between Tap46 and TOR. Tap46 depletion reproduced the signature phenotypes of TOR inactivation, such as dramatic repression of global translation and activation of autophagy and nitrogen mobilization, indicating that Tap46 may act as a positive effector of TOR signaling in controlling those processes. Additionally, Tap46 silencing in tobacco (Nicotiana tabacum) BY-2 cells caused chromatin bridge formation at anaphase, indicating its role in sister chromatid segregation. These findings suggest that Tap46, in conjunction with associated phosphatases, plays an essential role in plant growth and development as a component of the TOR signaling pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.