ArticleDiabetes care2011
High rate of regression from micro-macroalbuminuria to normoalbuminuria in children and adolescents with type 1 diabetes treated or not with enalapril: the influence of HDL cholesterol.
Article in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Trial
- Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes.Hormone research in paediatrics · 2017Trial
- Sex-Related Differences in Cardiovascular Disease Risk Profile in Children and Adolescents with Type 1 Diabetes.International journal of molecular sciences · 2021Review
- Elevated high-density lipoprotein in adolescents with Type 1 diabetes is associated with endothelial dysfunction in the presence of systemic inflammation.European heart journal · 2019Article
- Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association.Diabetes care · 2018Review
- The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes.Journal of diabetes and its complications · 2018Article
- Modifiable Risk Factors for Cardiovascular Disease in Children with Type 1 Diabetes: Can Early Intervention Prevent Future Cardiovascular Events?Current diabetes reports · 2017Review
- Hypertension and Diabetic Kidney Disease in Children and Adolescents.Diabetes spectrum : a publication of the American Diabetes Association · 2015Article
- Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus.Annals of pediatric endocrinology & metabolism · 2015Article
- Diabetic kidney disease in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2015Review
- Nephropathy in youth and young adults with type 2 diabetes.Current diabetes reports · 2014Review
- Type 1 diabetes and cardiovascular disease.Cardiovascular diabetology · 2013Review
- Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats.Clinical science (London, England : 1979) · 2013Article
- The effects of blocking Angiotensin receptors on early stages of diabetic nephropathy.International journal of preventive medicine · 2012Article
- Infant and toddler type 1 diabetes: complications after 20 years' duration.Diabetes care · 2012Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the frequency of normalization, the persistence of remission, and the impact on normalization of glycemic control and lipid profile, we analyzed data from a retrospective observational cohort study of type 1 diabetic children and adolescents with abnormal urinary albumin excretion (UAE). RESEARCH DESIGN AND
methodsAll diabetic children and adolescents (n = 41) who had persistent abnormal UAE in the period of 1984 to 2008 and followed up until 2009 (follow-up duration = 13.1 ± 6.2 years) were included in the study. Nine patients progressed to macroalbuminuria; 24 patients were administered ACE inhibitor treatment.
resultsThe cumulative prevalence of abnormal UAE was 9%. During follow-up, 14 of 17 untreated and 19 of 24 treated patients reverted to normoalbuminuria. In the remission group compared with the nonremission group, A1C levels during follow-up decreased (7.5 ± 1.0 vs. 9.4 ± 1.2%, P < 0.0001) and serum HDL cholesterol increased (52.7 ± 11.3 vs. 42.7 ± 8.6 mg/dL, P < 0.05). The micro-macroalbuminuric patients had lower HDL cholesterol (51.0 ± 11.4 vs. 62.4 ± 13.6 mg/dL, P < 0.0001) than 134 normoalbuminuric diabetic patients.
conclusionsMicroalbuminuria and macroalbuminuria were not permanent in most of our diabetic children and adolescents. If abnormal UAE values are high and persist for >1 year, only long-lasting treatment with ACE inhibitors seems able to induce persistent remission, especially when associated with good metabolic control and high HDL cholesterol levels.
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