Evidence map›Paper›PMID 21216638›Full record

ArticleVeterinary journal (London, England : 1997)2011

Canine specific ELISA for coagulation factor VII.

Tom Knudsen, Mads Kjelgaard-Hansen, Mikael Tranholm, Bo Wiinberg, Jes T Clausen, Jens Jacob Hansen, Timothy C Nichols, Marianne Kjalke, Asger L Jensen, Annemarie T Kristensen

Abstract read
In one paragraph

Article in Veterinary journal (London, England : 1997), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Tom KnudsenDepartment of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Copenhagen DK-1870, Denmark. tmkn@novonordisk.com
Mads Kjelgaard-Hansen
Mikael Tranholm
Bo Wiinberg
Jes T Clausen
Jens Jacob Hansen
Timothy C Nichols
Marianne Kjalke
Asger L Jensen
Annemarie T Kristensen
University of Copenhagen · DKNovo Nordisk (Denmark) · DKUniversity of North Carolina at Chapel Hill · US

Funding

Maintenance of Models of Human Hemophilia and VWDR24HL063098 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLS, TIMOTHY CHARLES · 1999 to 2019
$15.1M
NHLBI NIH HHS R24 HL063098NHLBI NIH HHS R24HL063098-12
6 · The paper itself

Abstract

Canine coagulation factor VII (FVII) deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated. FVII procoagulant activity can be measured by FVII activity (FVII:C), but assays for measurement of canine specific FVII antigen (FVII:Ag) have not been available to date. In this study, a canine specific ELISA for measurement of FVII:Ag in plasma was developed and validated. The FVII:Ag ELISA correctly diagnosed homozygous and heterozygous hereditary FVII deficiency. Together with activity based assays, such as FVII:C, the FVII:Ag ELISA should be valuable in the diagnosis of hereditary canine FVII deficiency.

Indexed as

AnimalsAntigensDog DiseasesDogsEnzyme-Linked Immunosorbent AssayFactor VIIFactor VII DeficiencyMiceReproducibility of ResultsAntigensFactor VIIfactor VII related antigen

Identifiers

PMID21216638
PMCPMC3947633
OpenAlexW2037309879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.