ReviewCurrent opinion in immunology2011
Epigenetic regulation of antigen receptor gene rearrangement.
Review in Current opinion in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Article
- RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations.Journal of molecular biology · 2017Review
- Histone methylation and V(D)J recombination.International journal of hematology · 2014Review
- Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.PLoS biology · 2014Article
- Stochastic gene expression in mammals: lessons from olfaction.Trends in cell biology · 2013Review
- The origin of recurrent translocations in recombining lymphocytes: a balance between break frequency and nuclear proximity.Current opinion in cell biology · 2013Review
- Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcripts.Frontiers in immunology · 2012Article
- Chromatin computation.PloS one · 2012Article
- Determinants of public T cell responses.Cell research · 2012Review
- The multiple shark Ig H chain genes rearrange and hypermutate autonomously.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Recent studies of the regulation of antigen receptor rearrangement have revealed several completely new levels of control. Not only do antigen receptor loci undergo changes in histone modifications as they become accessible for recombination, but also the number of different histone modifications and the variation at different parts of each receptor locus reveal great complexity. RAG2 is now known to bind to one of these histone modifications, H3K4me3, and this targets the initial RAG binding events to the J genes. The large megabase receptor loci undergo 3D changes in their structure during rearrangement, and receptor loci move throughout the nucleus, transiently binding to heterochromatin, and transiently pairing with each other. RAG-mediated DNA breaks promote some of these movements, and also result in widespread changes in the transcriptional profile promoting differentiation.
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Registered trials
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