ReviewTrends in genetics : TIG2011
Gene-environment interactions in human disease: nuisance or opportunity?
Review in Trends in genetics : TIG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- A call for greater diversity and representativeness within countries in psychiatric research: lessons and challenges from a systematic review of schizophrenia research in Brazil.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Pooled it
- Discerning asthma endotypes through comorbidity mapping.Nature communications · 2022Pooled it
- Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- Replication of acne susceptibility loci and gene-environment interactions with screen time in Singapore and Malaysia Chinese population.JID innovations : skin science from molecules to population health · 2026Article
- Nutrition as a Modifiable Factor in Optimizing Respiratory Health: Evidence from Pulmonary Function Tests.Children (Basel, Switzerland) · 2026Review
- Amniotic fluid modifies esophageal epithelium differentiation and inflammatory responses.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Detecting genetic effects on phenotype variability to capture gene-by-environment interactions: a systematic method comparison.G3 (Bethesda, Md.) · 2024Review
- Applying an evolutionary mismatch framework to understand disease susceptibility.PLoS biology · 2023Article
- Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response.The Journal of nutritional biochemistry · 2023Article
- Gene-Smoking Interaction Analysis for the Identification of Novel Asthma-Associated Genetic Factors.International journal of molecular sciences · 2023Article
- Maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development.Allergy · 2022Article
- Genetics of Asthma and Allergic Diseases.Handbook of experimental pharmacology · 2022Article
- Smooth-threshold multivariate genetic prediction incorporating gene-environment interactions.G3 (Bethesda, Md.) · 2021Article
- Dietary intake of vitamin A, lung function and incident asthma in childhood.The European respiratory journal · 2021Article
- Health Agency and Perfectionism: The Case of Perinatal Health Inequalities.Public health ethics · 2021Article
- A novel statistical method for modeling covariate effects in bisulfite sequencing derived measures of DNA methylation.Biometrics · 2021Article
- Third Follow-Up of the Study on Occupational Allergy Risks (SOLAR III) in Germany: Design, Methods, and Initial Data Analysis.Frontiers in public health · 2021Article
- Gene-Environment Interaction: A Variable Selection Perspective.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Genetic and Environmental Influences on Blood Pressure and Body Mass Index in the National Academy of Sciences-National Research Council World War II Veteran Twin Registry.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Building towards common psychosocial measures in U.S. cohort studies: principal investigators' views regarding the role of religiosity and spirituality in human health.BMC public health · 2020Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Many environmental risk factors for common, complex human diseases have been revealed by epidemiologic studies, but how genotypes at specific loci modulate individual responses to environmental risk factors is largely unknown. Gene-environment interactions will be missed in genome-wide association studies and could account for some of the 'missing heritability' for these diseases. In this review, we focus on asthma as a model disease for studying gene-environment interactions because of relatively large numbers of candidate gene-environment interactions with asthma risk in the literature. Identifying these interactions using genome-wide approaches poses formidable methodological problems, and elucidating molecular mechanisms for these interactions has been challenging. We suggest that studying gene-environment interactions in animal models, although more tractable, might not be sufficient to shed light on the genetic architecture of human diseases. Lastly, we propose avenues for future studies to find gene-environment interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.