ArticleAquatic toxicology (Amsterdam, Netherlands)2011
Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna).
Article in Aquatic toxicology (Amsterdam, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 103 citations in OpenAlex.
- Multi-level assessment of chronic toxicity of the insect growth regulator lufenuron in the non-target aquatic organism Daphnia magna.Environmental geochemistry and health · 2026Article
- Photosynthetic modulation and oxidative stress in Raphidocelis subcapitata exposed to environmentally relevant concentrations of a ketoconazole based commercial formulation.Ecotoxicology (London, England) · 2026Article
- Complex and lasting impacts of heatwaves on life-history traits and fitness in Daphnia magna.The Journal of experimental biology · 2025Article
- Effects of microplastics and natural particles on the aquatic invertebrate Daphnia magna under different dietary quality scenarios.Oecologia · 2025Article
- Pyriproxyfen Contamination inJournal of xenobiotics · 2024Article
- An In Vivo Whole-Transcriptomic Approach to Assess Developmental and Reproductive Impairments Caused by Flumequine inInternational journal of molecular sciences · 2023Article
- The Uptake of Sporopollenin Exine Capsules and Associated Bioavailability of Adsorbed Oestradiol in Selected Aquatic Invertebrates.Bulletin of environmental contamination and toxicology · 2021Article
- Susceptibility of the Non-Targeted CrustaceanGenes · 2021Article
- Mode of action evaluation for reduced reproduction in Daphnia pulex exposed to the insensitive munition, 1-methyl-3-nitro-1-nitroguanidine (MeNQ).Ecotoxicology (London, England) · 2021Article
- Greater toxic potency of bisphenol AF than bisphenol A in growth, reproduction, and transcription of genes in Daphnia magna.Environmental science and pollution research international · 2021Article
- A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology.Frontiers in endocrinology · 2021Review
- Paracetamol affects the expression of detoxification- and reproduction-related genes and alters the life traits of Daphnia magna.Ecotoxicology (London, England) · 2020Article
- Epigenetic, transcriptional and phenotypic responses in two generations ofEnvironmental epigenetics · 2019Article
- Evaluation of 4-nonylphenol and bisphenol A toxicity using multiple molecular biomarkers in the water flea Daphnia magna.Ecotoxicology (London, England) · 2019Article
- Developmental and reproductive effects of tamoxifen on Daphnia magna.Environmental monitoring and assessment · 2018Article
- New Perspectives on the Evolutionary History of Vitellogenin Gene Family in Vertebrates.Genome biology and evolution · 2018Article
- Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances.Integrated environmental assessment and management · 2017Article
- Vitellogenin and vitellogenin receptor gene expression and 20-hydroxyecdysone concentration in Macrobrachium rosenbergii exposed to chlordecone.Environmental science and pollution research international · 2016Article
- The HR97 (NR1L) group of nuclear receptors: a new group of nuclear receptors discovered in Daphnia species.General and comparative endocrinology · 2014Article
- Are pharmaceuticals with evolutionary conserved molecular drug targets more potent to cause toxic effects in non-target organisms?PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The induction of vitellogenin in oviparous vertebrates has become the gold standard biomarker of exposure to estrogenic chemicals in the environment. This biomarker of estrogen exposure also has been used in arthropods, however, little is known of the factors that regulate the expression of vitellogenin in these organisms. We investigated changes in accumulation of mRNA products of the vitellogenin gene Vtg2 in daphnids (Daphnia magna) exposed to a diverse array of chemicals. We further evaluated the involvement of hormonal factors in the regulation of vitellogenin expression that may be targets of xenobiotic chemicals. Expression of the Vtg2 gene was highly responsive to exposure to various chemicals with an expression range spanning approximately four orders of magnitude. Chemicals causing the greatest induction were piperonyl butoxide, chlordane, 4-nonylphenol, cadmium, and chloroform. Among these, only 4-nonylphenol is recognized to be estrogenic. Exposure to several chemicals also suppressed Vtg2 mRNA levels, as much as 100-fold. Suppressive chemicals included cyproterone acetate, acetone, triclosan, and atrazine. Exposure to the estrogens diethylstilbestrol and bisphenol A had little effect on vitellogenin mRNA levels further substantiating that these genes are not induced by estrogen exposure. Exposure to the potent ecdysteroids 20-hydroxyecdysone and ponasterone A revealed that Vtg2 was subject to strong suppressive control by these hormones. Vtg2 mRNA levels were not significantly affected from exposure to several juvenoid hormones. Results indicate that ecdysteroids are suppressors of vitellogenin gene expression and that vitellogenin mRNA levels can be elevated or suppressed in daphnids by xenobiotics that elicit antiecdysteroidal or ecdysteroidal activity, respectively. Importantly, daphnid Vtg2 is not elevated in response to estrogenic activity.
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Registered trials
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