ArticleJournal of vascular and interventional radiology : JVIR2011
Percutaneous mechanical and pharmacomechanical thrombolysis for occlusive deep vein thrombosis of the proximal limb in adolescent subjects: findings from an institution-based prospective inception cohort study of pediatric venous thromboembolism.
Article in Journal of vascular and interventional radiology : JVIR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Clinical care of pediatric patients with or at risk of postthrombotic syndrome: guidance from the ISTH SSC Subcommittee on pediatric and neonatal thrombosis and hemostasis.Journal of thrombosis and haemostasis : JTH · 2024Guideline
- Management of pulmonary thromboembolism in children: an evidence-based expert consensus.World journal of pediatrics : WJP · 2026Article
- Pediatric Venous Thromboembolism: Considerations for the Interventional Radiologist.Seminars in interventional radiology · 2025Review
- Selective iliofemoral stent placement for complex pediatric cases: a decade of institutional experience.Pediatric radiology · 2024Article
- Technical Feasibility and Clinical Efficacy of Iliac Vein Stent Placement in Adolescents and Young Adults with May-Thurner Syndrome.Cardiovascular and interventional radiology · 2024Article
- Clinical characteristics, management strategies and outcomes of patients with recurrent venous thromboembolism in the real world.Scientific reports · 2022Article
- Thrombolysis in Children: A Case Report and Review of the Literature.Frontiers in pediatrics · 2021Review
- Clinical Outcomes of May-Thurner Syndrome in Pediatric Patients: A Single Institutional Experience.TH open : companion journal to thrombosis and haemostasis · 2020Article
- Lower extremity endovenous reconstruction for symptomatic occlusive disease in pediatric patients: techniques, clinical outcomes, and long-term stent patencies.Pediatric radiology · 2019Article
- Mid-and long-term efficacy of endovascular-based procedures for Cockett syndrome.Scientific reports · 2018Article
- How We Manage Pediatric Deep Venous Thrombosis.Seminars in interventional radiology · 2017Review
- Pediatric Thrombolysis: A Practical Approach.Frontiers in pediatrics · 2017Review
- Guidance for the use of thrombolytic therapy for the treatment of venous thromboembolism.Journal of thrombosis and thrombolysis · 2016Review
- Outcomes in children with deep vein thrombosis managed with percutaneous endovascular thrombolysis.Pediatric radiology · 2015Article
- Developing a pediatric endovascular thrombolysis program: a single-center experience.Pediatric radiology · 2013Article
- The methylenetetrahydrofolate reductase polymorphism (MTHFR c.677C>T) and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism.Thrombosis research · 2013Article
- Current and future management of pediatric venous thromboembolism.American journal of hematology · 2012Review
- Deep vein thrombosis: thrombolysis in the pediatric population.Seminars in interventional radiology · 2012Article
- Massive Fatal Pulmonary Embolism While on Therapeutic Heparin Drip.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeYoung individuals with occlusive, proximal-limb deep vein thrombosis (DVT) who have acutely increased plasma levels of factor VIII and D-dimer are at high risk for postthrombotic syndrome (PTS) when treated with conventional anticoagulation alone. The present report is an evaluation of experience with adjunctive percutaneous mechanical thrombolysis (PMT) and/or percutaneous pharmacomechanical thrombolysis (PPMT) in such patients. PATIENTS AND
methodsAmong 95 children 11-21 years of age enrolled in a prospective cohort of venous thromboembolism between March 1, 2006, and November 1, 2009, 16 met eligibility criteria and underwent PMT/PPMT, typically with adjunctive catheter-directed thrombolytic infusion (CDTI) of tissue-type plasminogen activator given after the procedure.
resultsMedian age was 16 years (range, 11-19 y). Thirteen cases (81%) involved lower limbs. Underlying stenotic lesions were disclosed in 53%, with endovascular stents deployed in all cases of May-Thurner anomaly. There were no periprocedural major bleeding events and one symptomatic pulmonary embolism. Technical success rate was 94%. Early (< 30 days) locally recurrent DVT developed in 40% of cases, of which 83% were successfully treated with repeat lysis. Late recurrent DVT rate (median follow-up duration, 14 months; range, 1-42 mo) was 27%. Cumulative incidence of physically and functionally significant PTS at 1-2 years was 13%.
conclusionsThis experience provides preliminary evidence that PMT/PPMT with adjunctive CDTI can be used safely and effectively in adolescent subjects with DVT at high risk for PTS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.