ArticleFungal biology2011
A comparison between intratracheal and inhalation delivery of Aspergillus fumigatus conidia in the development of fungal allergic asthma in C57BL/6 mice.
Article in Fungal biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Single-cell and spatial transcriptomics define eosinophil heterogeneity during influenza A virus-induced exacerbation of fungal allergic asthma in C57BL/6 mice.Journal of leukocyte biology · 2026Article
- Direct Inoculation of Pathogenic Yeasts into Mouse Lung by Trans-tracheal Instillation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Adjuvant-independent airway sensitization and infection mouse models leading to allergic asthma.Frontiers in allergy · 2024Review
- Abnormal adenosine metabolism of neutrophils inhibits airway inflammation and remodeling in asthma model induced by Aspergillus fumigatus.BMC pulmonary medicine · 2023Article
- Purified Native and Recombinant MajorJournal of fungi (Basel, Switzerland) · 2021Article
- Review
- Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice.Scientific reports · 2019Article
- Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta.Scientific reports · 2018Article
- Article
- Humoral immune responses during asthma and influenza co-morbidity in mice.Immunobiology · 2017Article
- Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Subchronic exposures to fungal bioaerosols promotes allergic pulmonary inflammation in naïve mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Allergic Inflammation in Aspergillus fumigatus-Induced Fungal Asthma.Current allergy and asthma reports · 2015Review
- Hyaluronan stimulates ex vivo B lymphocyte chemotaxis and cytokine production in a murine model of fungal allergic asthma.Immunobiology · 2015Article
- B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma.Cellular & molecular immunology · 2015Article
- Overview of vertebrate animal models of fungal infection.Journal of immunological methods · 2014Review
- Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation induced by Aspergillus fumigatus.Immunology · 2014Article
- A murine inhalation model to characterize pulmonary exposure to dry Aspergillus fumigatus conidia.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Allergic asthma is a debilitating disease of the airways characterized by airway hyperresponsiveness, eosinophilic inflammation, goblet cell metaplasia with associated mucus hypersecretion, and airway wall remodelling events, particularly subepithelial fibrosis and smooth muscle cell hyperplasia. Animal models that accurately mimic these hallmarks of allergic airways disease are critical for studying mechanisms associated with the cellular and structural changes that lead to disease pathogenesis. Aspergillus fumigatus, is a common aeroallergen of human asthmatics. The intratracheal (IT) delivery of A. fumigatus conidia into the airways of sensitized mice has been described as a model of allergic disease. Here, we compared the IT model with a newly developed inhalation (IH) challenge model. The IH model allowed multiple fungal exposures, which resulted in an exacerbation to the allergic asthma phenotype. Increased recruitment of eosinophils and lymphocytes, the hallmark leukocytes of asthma, was noted with the IH model as compared to the IT model in which macrophages and neutrophils were more prominent. Immunoglobulin E (IgE) production was significantly greater after IH challenge, while that of IgG(2a) was higher after IT challenge. Airway wall remodelling was pronounced in IH-treated mice, particularly after multiple allergen challenges. Although the IT model may be appropriate for the examination of the played by innate cells in the acute response to fungus, it fails to consistently reproduce the chronic remodelling hallmarks of allergic asthma. The ability of the IH challenge to mimic these characteristics recommends it as a model suited to study these important events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.