ArticleCell2011
Mitochondrial stress signals revise an old aging theory.
Article in Cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Crosstalk between cancer‑associated fibroblasts and inflammation in tumor microenvironment: A novel perspective in cancer therapy (Review).Oncology reports · 2025Review
- Effect of ambient lead on progesterone and pregnancy-associated glycoprotein 1 and their relationship with abortion in Zaraibi goats: a field study.Tropical animal health and production · 2024Article
- Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection.Advances in experimental medicine and biology · 2023Article
- MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.International journal of molecular sciences · 2022Review
- Article
- Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1.JCI insight · 2021Article
- Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes.Cell reports · 2021Article
- Cadmium induces mitochondrial ROS inactivation of XIAP pathway leading to apoptosis in neuronal cells.The international journal of biochemistry & cell biology · 2020Article
- MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- Mitochondria: multifaceted regulators of aging.BMB reports · 2019Review
- Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes.Clinical science (London, England : 1979) · 2018Article
- Human aging and disease: Lessons from age-related macular degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Current Perspective in the Discovery of Anti-aging Agents from Natural Products.Natural products and bioprospecting · 2017Review
- Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series.Journal of the American College of Cardiology · 2017Review
- The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging.Redox biology · 2017Article
- Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway.British journal of pharmacology · 2017Article
- Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy.Oxidative medicine and cellular longevity · 2017Review
- MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.Free radical biology & medicine · 2016Review
- Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A.Neuropharmacology · 2016Article
- The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain.Oncotarget · 2016Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
In this issue, Durieux et al. (2011) describe a tissue-specific signal, originating from mitochondria, that acts cell non-autonomously to regulate life span in the nematode, C. elegans. This new finding provides a first step toward resolving the relative contributions of mitochondrial free radical damage and signaling mechanisms in aging.
Identifiers
21215364What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.