Evidence map›Paper›PMID 21215322›Full record

ArticlePulmonary pharmacology & therapeutics2011

Workshop: tuning the 'cough center'.

J Widdicombe, M Tatar, G Fontana, J Hanacek, P Davenport, F Lavorini, D Bolser, Other participants

Abstract read
In one paragraph

Article in Pulmonary pharmacology & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

J WiddicombeUniversity of London, 116 Pepys Road, London SW20 8NY, UK. JohnWiddicombeJ@aol.com
M Tatar
G Fontana
J Hanacek
P Davenport
F Lavorini
D Bolser
Other participants
University of Florida · USUniversity of London · GB

Funding

Central Mechanisms of Airway ProtectionR01HL103415 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, DAVENPORT, PAUL W · 2010 to 2013
$2.2M
Neurogenesis of CoughR33HL089104 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C · 2008 to 2010
$1.6M
NHLBI NIH HHS R01 HL103415NHLBI NIH HHS R33 HL089104
6 · The paper itself

Abstract

The Workshop considered the mechanisms whereby the 'cough center' could be tuned by various afferent inputs. There were particular presentations on the effects of inputs from the nose, mouth, respiratory tract and lungs, cerebral cortex, somatic tissues and the pharynx. From all these sites cough induced from the lungs could be increased or decreased in its strength or modified in its pattern. Thus 'tuning' of cough could be due to the interaction of afferent inputs, or to the sensitization or desensitization of brainstem neural pathways. The pattern of response depended on the 'type' of cough being studied and, in some instances, on the timing of the sensory input into the brainstem. Cough inputs could also affect various 'non-cough' motor outputs from the brain, although this was not the main theme of the Workshop. The main conclusion was that cough is not a stereotyped output from the medullary 'cough center', but that its pattern and strength depend on many afferent inputs acting on the 'cough center'.

Indexed as

Afferent PathwaysBrain StemCoughHumansReflexRespiratory System

Identifiers

PMID21215322
PMCPMC3132403
OpenAlexW2044343189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.