ArticleOsteoarthritis and cartilage2011
Canine hip dysplasia is predictable by genotyping.
Article in Osteoarthritis and cartilage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs.PloS one · 2024Article
- Genomic analysis and prediction of genomic values for distichiasis in Staffordshire bull terriers.Canine medicine and genetics · 2023Article
- Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science.Frontiers in veterinary science · 2021Review
- Genomic Prediction of Two Complex Orthopedic Traits Across Multiple Pure and Mixed Breed Dogs.Frontiers in genetics · 2021Article
- Assessment of the Potential for Genomic Selection To Improve Husk Traits in Maize.G3 (Bethesda, Md.) · 2020Article
- Prevalence of canine hip dysplasia in 10 breeds in France, a retrospective study of the 1997-2017 radiographic screening period.PloS one · 2020Article
- The association of genetic polymorphisms of bone formation genes with canine hip dysplasia.Iranian journal of veterinary research · 2020Article
- Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci.BMC genomics · 2019Article
- Genome-wide association studies and genetic testing: understanding the science, success, and future of a rapidly developing field.Journal of the American Veterinary Medical Association · 2019Review
- Expanding the BLUP alphabet for genomic prediction adaptable to the genetic architectures of complex traits.Heredity · 2018Article
- Evaluation of the Potential for Genomic Selection to Improve Spring Wheat Resistance to Fusarium Head Blight in the Pacific Northwest.Frontiers in plant science · 2018Article
- Joint Genomic Prediction of Canine Hip Dysplasia in UK and US Labrador Retrievers.Frontiers in genetics · 2018Article
- Article
- Genotype imputation in the domestic dog.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- A retrospective study on findings of canine hip dysplasia screening in Kenya.Veterinary world · 2015Article
- Emerging insights into the genetic basis of canine hip dysplasia.Veterinary medicine (Auckland, N.Z.) · 2015Review
- A genetic predictive model for canine hip dysplasia: integration of Genome Wide Association Study (GWAS) and candidate gene approaches.PloS one · 2015Article
- Enrichment of statistical power for genome-wide association studies.BMC biology · 2014Article
- Hip joint replacement using monofilament polypropylene surgical mesh: an animal model.BioMed research international · 2014Article
- Monitoring Hip and Elbow Dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo establish a predictive method using whole genome genotyping for early intervention in canine hip dysplasia (CHD) risk management, for the prevention of the progression of secondary osteoarthritis (OA), and for selective breeding.
designTwo sets of dogs (six breeds) were genotyped with dense SNPs covering the entire canine genome. The first set contained 359 dogs upon which a predictive formula for genomic breeding value (GBV) was derived by using their estimated breeding value (EBV) of the Norberg angle (a measure of CHD) and their genotypes. To investigate how well the formula would work for an individual dog with genotype only (without using EBV), a cross validation was performed by masking the EBV of one dog at a time. The genomic data and the EBV of the remaining dogs were used to predict the GBV for the single dog that was left out. The second set of dogs included 38 new Labrador retriever dogs, which had no pedigree relationship to the dogs in the first set.
resultsThe cross validation showed a strong correlation (R>0.7) between the EBV and the GBV. The independent validation showed a moderate correlation (R=0.5) between GBV for the Norberg angle and the observed Norberg angle (no EBV was available for the new 38 dogs). Sensitivity, specificity, positive and negative predictive values of the genomic data were all above 70%.
conclusionsPrediction of CHD from genomic data is feasible, and can be applied for risk management of CHD and early selection for genetic improvement to reduce the prevalence of CHD in breeding programs. The prediction can be implemented before maturity, at which age current radiographic screening programs are traditionally applied, and as soon as DNA is available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.