ArticleBehavioural processes2011
Locomotor activity in a novel environment predicts both responding for a visual stimulus and self-administration of a low dose of methamphetamine in rats.
Article in Behavioural processes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 34 citations in OpenAlex.
- Histopathological effects of hypervitaminosis-D and the protective role of fetuin-A in renal, hepatic, and cardiac tissues in a murine model.Scientific reports · 2025Article
- Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats.Scientific reports · 2024Article
- Novelty-induced locomotor behavior predicts heroin addiction vulnerability in male, but not female, rats.Psychopharmacology · 2022Article
- Prenatal ethanol exposure impairs sensory processing and habituation to visual stimuli, effects normalized by enrichment of postnatal environmental.Alcoholism, clinical and experimental research · 2022Article
- The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice.Behavioural brain research · 2021Article
- Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats.EBioMedicine · 2020Article
- NMDA Receptor-Dependent Cholinergic Modulation of Mesolimbic Dopamine Cell Bodies: Neurochemical and Behavioral Studies.ACS chemical neuroscience · 2019Article
- Prenatal ethanol exposure increases risk of psychostimulant addiction.Behavioural brain research · 2019Article
- Methamphetamine self-administration in a runway model of drug-seeking behavior in male rats.Pharmacology, biochemistry, and behavior · 2018Article
- Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure.Drug and alcohol dependence · 2018Article
- Enhancement of a visual reinforcer by D-amphetamine and nicotine in adult rats: relation to habituation and food restriction.Psychopharmacology · 2018Article
- Interaction of chronic food restriction and methylphenidate in sensation seeking of rats.Psychopharmacology · 2017Article
- Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration in rats.Experimental and therapeutic medicine · 2017Article
- Chronic variable stress and intravenous methamphetamine self-administration - Role of individual differences in behavioral and physiological reactivity to novelty.Neuropharmacology · 2016Article
- Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel.Psychopharmacology · 2016Article
- Individual differences in the behavioral effects of nicotine: A review of the preclinical animal literature.Pharmacology, biochemistry, and behavior · 2015Review
- Cocaine-induced locomotor activity in rats selectively bred for low and high voluntary running behavior.Psychopharmacology · 2015Article
- Nicotine and methamphetamine disrupt habituation of sensory reinforcer effectiveness in male rats.Experimental and clinical psychopharmacology · 2014Article
- Habituation of reinforcer effectiveness.Frontiers in integrative neuroscience · 2014Review
- Fostering itself increases nicotine self-administration in young adult male rats.Psychopharmacology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There is evidence that visual stimuli used to signal drug delivery in self-administration procedures have primary reinforcing properties, and that drugs of abuse enhance the reinforcing properties of such stimuli. Here, we explored the relationships between locomotor activity, responding for a visual stimulus, and self-administration of methamphetamine (METH). Rats were classified as high or low responders based on activity levels in a novel locomotor chamber and were subsequently tested for responding to produce a visual stimulus followed by self-administration of a low dose of METH (0.025 mg/kg/infusion) paired with the visual stimulus. High responder rats responded more for the visual stimulus than low responder rats indicating that the visual stimulus was reinforcing and that operant responding for a visual stimulus has commonalities with locomotor activity in a novel environment. Similarly, high responder rats responded more for METH paired with a visual stimulus than low responder rats. Because of the reinforcing properties of the visual stimulus, it was not possible to determine if the rats were responding to produce the visual stimulus, METH or the combination. We speculate that responding to produce sensory reinforcers may be a measure of sensation seeking. These results indicate that visual stimuli have unconditioned reinforcing effects which may have a significant role in acquisition of drug self-administration, a role that is not yet well understood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.