ArticleDevelopmental biology2011
Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
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- Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease.PLoS genetics · 2021Article
- Application of Fluorescent Proteins for Functional Dissection of theInternational journal of molecular sciences · 2021Review
- Fly-QMA: Automated analysis of mosaic imaginal discs in Drosophila.PLoS computational biology · 2020Article
- Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress.Autophagy · 2019Article
- TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.PLoS genetics · 2019Article
- Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina.PLoS genetics · 2018Article
- Unraveling Novel Mechanisms of Neurodegeneration Through a Large-Scale Forward Genetic Screen inFrontiers in genetics · 2018Review
- Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge.Developmental biology · 2017Article
- Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.Scientific reports · 2017Article
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- Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors.PLoS genetics · 2016Article
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- An intergenic regulatory region mediates Drosophila Myc-induced apoptosis and blocks tissue hyperplasia.Oncogene · 2015Article
- A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells.Channels (Austin, Tex.) · 2015Article
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- The Tomato/GFP-FLP/FRT method for live imaging of mosaic adult Drosophila photoreceptor cells.Journal of visualized experiments : JoVE · 2013Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We report a new two-color fluorescent imaging system to visualize the mosaic adult photoreceptor neurons (PRs) in real-time. Using this method, we examined a collection of 434 mutants and identified genes required for PR survival, planar cell polarity (PCP), patterning and differentiation. We could track the progression of PR degeneration in living flies. By introducing the expression of p35, a caspase inhibitor, we found mutations that specifically activate caspase-dependent death. Moreover, we showed that grh is required in R3 for correct PCP establishment. The "Tomato/GFP-FLP/FRT" method allows high-throughput, rapid and precise identification of survival and developmental pathways in living adult PRs at single-cell resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.