ArticleDevelopmental biology2011
A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 71 citations in OpenAlex.
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- Sox9 is associated with two distinct patterning events during snake lung morphogenesis.Developmental biology · 2024Article
- Human pluripotent stem cell fate trajectories toward lung and hepatocyte progenitors.iScience · 2023Article
- Computational approaches to understand transcription regulation in development.Biochemical Society transactions · 2023Review
- The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and disease.Frontiers in immunology · 2023Review
- The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during Xenopus lung development.Development, growth & differentiation · 2022Article
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- Fumarylacetoacetate hydrolase gene as a knockout target for hepatic chimerism and donor liver production.Stem cell reports · 2021Review
- Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification.Development (Cambridge, England) · 2020Article
- Early Xenopus gene regulatory programs, chromatin states, and the role of maternal transcription factors.Current topics in developmental biology · 2020Review
- Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation.Developmental cell · 2019Article
- Deregulated NKL Homeobox Genes in B-Cell Lymphoma.Cancers · 2019Review
- Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1.Journal of molecular cell biology · 2019Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Decellularized human liver extracellular matrix (hDLM)-mediated hepatic differentiation of human induced pluripotent stem cells (hIPSCs).Journal of tissue engineering and regenerative medicine · 2018Article
- Translating Developmental Principles to Generate Human Gastric Organoids.Cellular and molecular gastroenterology and hepatology · 2018Review
- A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells.Cell reports · 2018Article
- Timing is everything: Reiterative Wnt, BMP and RA signaling regulate developmental competence during endoderm organogenesis.Developmental biology · 2018Article
- Tissue-Specific Gene Inactivation inGenetics · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The homeobox gene hhex is one of the earliest markers of the anterior endoderm, which gives rise to foregut organs such as the liver, ventral pancreas, thyroid, and lungs. The regulatory networks controlling hhex transcription are poorly understood. In an extensive cis-regulatory analysis of the Xenopus hhex promoter, we determined how the Nodal, Wnt, and BMP pathways and their downstream transcription factors regulate hhex expression in the gastrula organizer. We show that Nodal signaling, present throughout the endoderm, directly activates hhex transcription via FoxH1/Smad2 binding sites in the proximal -0.44 Kb promoter. This positive action of Nodal is suppressed in the ventral-posterior endoderm by Vent 1 and Vent2, homeodomain repressors that are induced by BMP signaling. Maternal Wnt/β-catenin on the dorsal side of the embryo cooperates with Nodal and indirectly activates hhex expression via the homeodomain activators Siamois and Twin. Siamois/Twin stimulate hhex transcription through two mechanisms: (1) they induce the expression of Otx2 and Lim1 and together Siamois, Twin, Otx2, and Lim1 appear to promote hhex transcription through homeobox sites in a Wnt-responsive element located between -0.65 to -0.55 Kb of the hhex promoter. (2) Siamois/Twin also induce the expression of the BMP-antagonists Chordin and Noggin, which are required to exclude Vents from the organizer allowing hhex transcription. This study reveals a complex network regulating anterior endoderm transcription in the early embryo.
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