ReviewBMC infectious diseases2011
Burden of rotavirus gastroenteritis in the Middle Eastern and North African pediatric population.
Review in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Burden of rotavirus gastroenteritis on caregivers: Findings from a systematic literature review.Human vaccines & immunotherapeutics · 2022Pooled it
- Systematic review of the rotavirus infection burden in the WHO-EMRO region.Human vaccines & immunotherapeutics · 2019Pooled it
- Assessing the Impact of Rotavirus Vaccination in Iranian Children Under Five: An Agent-Based Modelling Approach.Health science reports · 2026Article
- Healthcare resource utilization and caregiver burden associated with rotavirus gastroenteritis hospitalizations in Taiwan.BMC pediatrics · 2025Observational
- Post-infectious irritable bowel syndrome in a paediatric population: first data in a Middle Eastern country.BMC pediatrics · 2025Article
- Prevalence of Acute Gastroenteritis Enteropathogens Among Hospitalized Children in Jordan: A Single-Center Study.Viruses · 2025Article
- Health economic evaluation of 2-dose and 3-dose rotavirus vaccines in children below 5 years of age in Morocco.Human vaccines & immunotherapeutics · 2024Article
- Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar.Pediatric research · 2023Article
- Prevalence of Rotavirus-Associated Acute Gastroenteritis Cases in Early Childhood in Turkey: Meta-Analysis.Children (Basel, Switzerland) · 2020Article
- Genotyping of Rotaviruses in River Nile in Giza, Egypt.Iranian journal of public health · 2020Article
- Molecular Detection and Epidemiological Features of Selected Bacterial, Viral, and Parasitic Enteropathogens in Stool Specimens from Children with Acute Diarrhea in Thi-Qar Governorate, Iraq.International journal of environmental research and public health · 2019Article
- Childhood Diarrhoea in the Eastern Mediterranean Region with Special Emphasis on Non-Typhoidal Salmonella at the Human⁻Food Interface.Pathogens (Basel, Switzerland) · 2019Review
- Human rotavirus in Iran; molecular epidemiology, genetic diversity and recent updates on vaccine advances.Gastroenterology and hepatology from bed to bench · 2019Review
- Hospitalizations and Deaths Associated with Diarrhea and Respiratory Diseases among Children Aged 0⁻5 Years in a Referral Hospital of Mauritania.Tropical medicine and infectious disease · 2018Article
- DiarrheagenicJournal of public health in Africa · 2017Article
- Observational
- Detection and sequencing of rotavirus among sudanese children.The Pan African medical journal · 2017Article
- The cost effectiveness of rotavirus vaccination in Iran.Human vaccines & immunotherapeutics · 2016Article
- Article
- Unusual rotavirus genotypes among children with acute diarrhea in Saudi Arabia.BMC infectious diseases · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRotavirus gastroenteritis (RVGE) is the most common cause of severe childhood diarrhea worldwide. Objectives were to estimate the burden of RVGE among children less than five years old in the Middle East (Bahrain, Iran, Iraq, Israel, Jordan, Kuwait, Oman, Qatar, Saudi Arabia, Syria, UAE, Yemen), North Africa (Algeria, Egypt, Libya, Morocco, Tunisia) and Turkey.
methodsA comprehensive literature search was conducted in major databases on the epidemiology and burden of rotavirus among children less than five years old between 1999 and 2009. Data from each country was extracted and compared.
resultsThe search identified 43 studies. RVGE was identified in 16-61% of all cases of acute gastroenteritis, with a peak in the winter. RVGE-related hospitalization rates ranged from 14% to 45%, compared to 14%-28% for non-RVGE. Annually, RVGE caused up to 112 fatalities per 100,000 in certain countries in the region. Hospitalization costs ranged from $1.8 to $4.6 million annually, depending on the country. The most recent literature available showed that G1P[8] was the most prevalent genotype combination in 8 countries (range 23%-56%). G2P[4] was most prevalent in 4 countries (26%-48%). G9P[8] and G4P[8] were also frequently detected.
conclusionsRVGE is a common disease associated with significant morbidity, mortality, and economic burden. Given the variety and diverse rotavirus types in the region, use of a vaccine with broad and consistent serotype coverage would be important to help decrease the burden of RVGE in the Middle East and North Africa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.