ArticleImmunity & ageing : I & A2011
Aging impacts isolated lymphoid follicle development and function.
Article in Immunity & ageing : I & A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Intestinal aging-related immune dysfunction: mechanisms and interventions.Acta biochimica et biophysica Sinica · 2026Review
- Moderate Aerobic Exercise Induces Homeostatic IgA Generation in Senile Mice.International journal of molecular sciences · 2024Article
- Small Intestinal Goblet Cells Control Humoral Immune Responses and Mobilization During Enteric Infection.bioRxiv : the preprint server for biology · 2024Article
- The intestinal immune system and gut barrier function in obesity and ageing.The FEBS journal · 2023Review
- Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota.Nature cell biology · 2023Article
- Dietary supplementation with spray-dried animal plasma improves vaccine protection in aged mice.Frontiers in nutrition · 2023Article
- Exercise improves intestinal IgA production by T-dependent cell pathway in adults but not in aged mice.Frontiers in endocrinology · 2023Article
- Effects of aging on urinary tract epithelial homeostasis and immunity.Developmental biology · 2023Review
- Immunoglobulin G Is Increased in the Injured Spinal Cord in a Sex- and Age-Dependent Manner.Journal of neurotrauma · 2022Article
- Review
- Human gut-associated lymphoid tissues (GALT); diversity, structure, and function.Mucosal immunology · 2021Review
- A missense variant inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation.Mucosal immunology · 2020Article
- Signature changes in the expressions of protein-coding genes, lncRNAs, and repeat elements in early and late cellular senescence.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- The First Report of Immunoglobulin G, M, and A Concentrations in Serum of European Bison and Their Changes with Age.Journal of immunology research · 2020Article
- Transcriptome Network Analysis Identifies CXCL13-CXCR5 Signaling Modules in the Prostate Tumor Immune Microenvironment.Scientific reports · 2019Article
- CFTR regulates B cell activation and lymphoid follicle development.Respiratory research · 2019Article
- Dietary Animal Plasma Proteins Improve the Intestinal Immune Response in Senescent Mice.Nutrients · 2017Article
- The intranasal adjuvant Endocine™ enhances both systemic and mucosal immune responses in aged mice immunized with influenza antigen.Virology journal · 2017Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundImmunosenescence is the age-related decline and dysfunction of protective immunity leading to a marked increase in the risk of infections, autoimmune disease, and cancer. The majority of studies have focused on immunosenescence in the systemic immune system; information concerning the effect of aging on intestinal immunity is limited. Isolated lymphoid follicles (ILFs) are newly appreciated dynamic intestinal lymphoid structures that arise from nascent lymphoid tissues, or cryptopatches (CP), in response to local inflammatory stimuli. ILFs promote "homeostatic" responses including the production of antigen-specific IgA, thus playing a key role in mucosal immune protection. ILF dysfunction with aging could contribute to immunosenescence of the mucosal system, and accordingly we examined phenotypic and functional aspects of ILFs from young (2 month old) and aged (2 year old) mice.
resultsWe observed that aged mice have increased numbers of ILFs and increased numbers of structures corresponding to an early stage of CPs transforming into ILFs. The cellular composition of ILFs in aged mice is altered with a smaller B-lymphocyte population and an increased T-lymphocyte population. The ILF T-lymphocyte population is notable by the presence of CD4+ CD8αα+ T-lymphocytes, which are absent from the systemic compartment. The smaller B-lymphocyte population in ILFs from aged mice is directly correlated with decreased mRNA and protein expression of CCL20 and CXCL13, two chemokines that play crucial roles in recruiting B-lymphocytes into ILFs. Aged mice had elevated levels of serum and fecal immunoglobulins and despite the decreased B-lymphocyte population, ILFs from aged mice displayed increased IgA production. The immunoglobulin repertoire was skewed in aged mice, and ILFs demonstrated a repertoire usage similar to that of the systemic pool in both young and aged mice.
conclusionsHere we observed that ILF development, cellular composition, and immunoglobulin production are altered with aging suggesting that ILF dysfunction contributes to mucosal immunosenescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.