ArticleVirology journal2011
Complete coding sequence characterization and comparative analysis of the putative novel human rhinovirus (HRV) species C and B.
Article in Virology journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults: rhinovirus among adults and children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Observational
- Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C.Scientific reports · 2015Article
- Spread of different rhinovirus B genotypes in hospitalized children in Spain.Influenza and other respiratory viruses · 2013Article
- Proposals for the classification of human rhinovirus species A, B and C into genotypically assigned types.The Journal of general virology · 2013Article
- Biological characteristics and propagation of human rhinovirus-C in differentiated sinus epithelial cells.Virology · 2013Article
- Molecular epidemiology and evolution of human enterovirus serotype 68 in Thailand, 2006-2011.PloS one · 2012Article
- PCR for detection of respiratory viruses: seasonal variations of virus infections.Expert review of anti-infective therapy · 2011Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman Rhinoviruses (HRVs) are well recognized viral pathogens associated with acute respiratory tract illnesses (RTIs) abundant worldwide. Although recent studies have phylogenetically identified the new HRV species (HRV-C), data on molecular epidemiology, genetic diversity, and clinical manifestation have been limited.
resultTo gain new insight into HRV genetic diversity, we determined the complete coding sequences of putative new members of HRV species C (HRV-CU072 with 1% prevalence) and HRV-B (HRV-CU211) identified from clinical specimens collected from pediatric patients diagnosed with a symptom of acute lower RTI. Complete coding sequence and phylogenetic analysis revealed that the HRV-CU072 strain shared a recent common ancestor with most closely related Chinese strain (N4). Comparative analysis at the protein level showed that HRV-CU072 might accumulate substitutional mutations in structural proteins, as well as nonstructural proteins 3C and 3 D. Comparative analysis of all available HRVs and HEVs indicated that HRV-C contains a relatively high G+C content and is more closely related to HEV-D. This might be correlated to their replication and capability to adapt to the high temperature environment of the human lower respiratory tract. We herein report an infrequently occurring intra-species recombination event in HRV-B species (HRV-CU211) with a crossing over having taken place at the boundary of VP2 and VP3 genes. Moreover, we observed phylogenetic compatibility in all HRV species and suggest that dynamic mechanisms for HRV evolution seem to be related to recombination events. These findings indicated that the elementary units shaping the genetic diversity of HRV-C could be found in the nonstructural 2A and 3D genes.
conclusionThis study provides information for understanding HRV genetic diversity and insight into the role of selection pressure and recombination mechanisms influencing HRV evolution.
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