ArticleMolecular oral microbiology2011
Transcriptome analysis of LuxS-deficient Streptococcus mutans grown in biofilms.
Article in Molecular oral microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 72 citations in OpenAlex.
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- Environmental and genetic influence on the rate and spectrum of spontaneous mutations inMicrobiology (Reading, England) · 2024Article
- Silent signals: howFrontiers in oral health · 2024Review
- Biofilm Formation inMicroorganisms · 2023Article
- Fixed Orthodontic Treatment Increases Cariogenicity and Virulence Gene Expression in Dental Biofilm.Journal of clinical medicine · 2022Article
- Identification of a new probiotic strain,Frontiers in microbiology · 2022Article
- Transcriptome analysis of heat resistance regulated by quorum sensing system inFrontiers in microbiology · 2022Article
- RNase III coding genes modulate the cross-kingdom biofilm ofFrontiers in microbiology · 2022Article
- Molecular mechanisms of inhibiting glucosyltransferases for biofilm formation in Streptococcus mutans.International journal of oral science · 2021Review
- mRNA-Seq reveals the quorum sensing system luxS gene contributes to the environmental fitness of Streptococcus suis type 2.BMC microbiology · 2021Article
- Probiotic Effects of Lactobacillus paracasei 28.4 to Inhibit Streptococcus mutans in a Gellan-Based Formulation.Probiotics and antimicrobial proteins · 2021Article
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- Effects of Rhein-8-O-β-D-glucopyranoside on the Biofilm Formation of Streptococcus mutans.Current microbiology · 2021Article
- Acyl homoserine lactone-mediated quorum sensing in the oral cavity: a paradigm revisited.Scientific reports · 2020Article
- Short-ChainApplied and environmental microbiology · 2020Article
- The Biology ofMicrobiology spectrum · 2019Article
- Synthesis, antibacterial activity, and biocompatibility of new antibacterial dental monomers.American journal of dentistry · 2018Article
- Deficiency of BrpA in Streptococcus mutans reduces virulence in rat caries model.Molecular oral microbiology · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We previously reported that LuxS in Streptococcus mutans is involved in stress tolerance and biofilm formation. In this study, flowcells and confocal laser scanning microscopy were used to further examine the effects of LuxS-deficiency on biofilm formation. Similar to the wild-type strain (UA159), a strain deficient in LuxS (TW26D) bound efficiently to the flowcells and formed microcolonies 4 h after inoculation. Unlike UA159, which accumulated and formed compact, evenly distributed biofilms after 28 h, TW26D showed only loose, sporadic, thin biofilms. DNA microarray analysis revealed alterations in transcription of more than 60 genes in TW26D biofilms by at least 1.5-fold (P < 0.001). Among the upregulated genes were those for sugar-specific enzymes II of the phosphotransferase (PTS) system and the atp operon, which codes for the proton-pumping F-ATPase. Of the downregulated genes, several encode proteins with putative functions in DNA repair. Mutation of selected genes caused severe defects in the ability of the mutants to tolerate low pH and oxidative stress. These results provide additional proof that LuxS-deficiency causes global alterations in the expression of genes central to biofilm formation and virulence of S. mutans, including those involved in energy metabolism, DNA repair and stress tolerance.
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