Evidence map›Paper›PMID 21214222›Full record

ArticleOrganic letters2011

The components of xRNA: synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides.

Armando R Hernández, Eric T Kool

Abstract read
In one paragraph

Article in Organic letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Isothiazologuanosine (Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Interbase FRET in RNA: from A to Z.Nucleic acids research · 2019
    Article
  4. Review
  5. Artificial genetic sets composed of size-expanded base pairs.Angewandte Chemie (International ed. in English) · 2013
    Review
  6. Article
  7. Emissive RNA alphabet.Journal of the American Chemical Society · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Armando R HernándezDepartment of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
Eric T Kool

Funding

RE-ENGINEERING THE DIAMETER OF THE DOULBE HELIXR01GM063587 · NIGMS · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2001 to 2010
$2.2M
Probing the Steric Restrictions of RISC using xRNA-Containing siRNAsF31GM084680 · NIGMS · STANFORD UNIVERSITY · PI HERNANDEZ, ARMANDO RICARDO · 2008 to 2011
$165k
NIGMS NIH HHS F31 GM084680NIGMS NIH HHS GM063587NIGMS NIH HHS GM084680NIGMS NIH HHS R01 GM063587
6 · The paper itself

Abstract

The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.

Indexed as

FluorescenceFluorescent DyesMolecular StructureRibonucleosidesStructure-Activity RelationshipFluorescent DyesRibonucleosides

Identifiers

PMID21214222
PMCPMC3039074

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.