ArticleChemical communications (Cambridge, England)2011
Controlled enzymatic synthesis of natural-linkage, defined-length polyubiquitin chains using lysines with removable protecting groups.
Article in Chemical communications (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- AmideBiomolecular NMR assignments · 2026Article
- Convergent Assembly of Homo- and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol-Ene Chemistry.Angewandte Chemie (International ed. in English) · 2025Article
- Reading and Writing the Ubiquitin Code Using Genetic Code Expansion.Chembiochem : a European journal of chemical biology · 2024Review
- Biocompatible Lysine Protecting Groups for the Chemoenzymatic Synthesis of K48/K63 Heterotypic and Branched Ubiquitin Chains.ACS central science · 2023Article
- Functional analysis of protein post-translational modifications using genetic codon expansion.Protein science : a publication of the Protein Society · 2023Review
- Generation of site-specific ubiquitinated histones through chemical ligation to probe the specificities of histone deubiquitinases.Frontiers in epigenetics and epigenomics · 2023Article
- Linkage-Specific Synthesis of Di-ubiquitin Probes Enabled by the Incorporation of Unnatural Amino Acid ThzK.Chembiochem : a European journal of chemical biology · 2022Article
- Site-Specific Detection and Characterization of Ubiquitin Carbamylation.Biochemistry · 2022Article
- Artificially Linked Ubiquitin Dimers Characterised Structurally and Dynamically by NMR Spectroscopy.Chembiochem : a European journal of chemical biology · 2019Article
- Ubiquitin Chains Bearing Genetically Encoded Photo-Cross-Linkers Enable Efficient Covalent Capture of (Poly)ubiquitin-Binding Domains.Biochemistry · 2019Article
- Analysis of the topology of ubiquitin chains.Methods in enzymology · 2019Article
- Genetically Directed Production of Recombinant, Isosteric and Nonhydrolysable Ubiquitin Conjugates.Chembiochem : a European journal of chemical biology · 2016Article
- Chemical ubiquitination for decrypting a cellular code.The Biochemical journal · 2016Review
- A Rapid and Versatile Method for Generating Proteins with Defined Ubiquitin Chains.Biochemistry · 2016Article
- Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.Structure (London, England : 1993) · 2016Article
- Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine.Organic & biomolecular chemistry · 2015Article
- Preparing to read the ubiquitin code: a middle-out strategy for characterization of all lysine-linked diubiquitins.Journal of mass spectrometry : JMS · 2014Article
- Alanine scan of core positions in ubiquitin reveals links between dynamics, stability, and function.Journal of molecular biology · 2014Article
- Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.Angewandte Chemie (International ed. in English) · 2013Article
- Nonenzymatic assembly of branched polyubiquitin chains for structural and biochemical studies.Bioorganic & medicinal chemistry · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
E2 enzymes catalyze the ATP-dependent polymerization of polyubiquitin chains which function as molecular signals in the regulation of numerous cellular processes. Here we present a method that uses genetically encoded unnatural amino acids to halt and re-start ubiquitin polymerization providing access to natural-linkage, precision-length ubiquitin chains that can be used for biochemical, structural, and dynamics studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.