ReviewTransactions of the American Ophthalmological Society2010
Studies on the pathogenesis of avascular retina and neovascularization into the vitreous in peripheral severe retinopathy of prematurity (an american ophthalmological society thesis).
Review in Transactions of the American Ophthalmological Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed, 47 citations in OpenAlex.
- Incidence and Risk Factors for Persistent Avascular Retina in Patients with a History of Retinopathy of Prematurity in Mexico.Diagnostics (Basel, Switzerland) · 2026Article
- Identification of mechanical ventilation-related risk factors for retinopathy of prematurity in preterm infants.Translational pediatrics · 2026Article
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis.Acta pharmacologica Sinica · 2026Article
- Severe Retinal Vascular Dysplasia in a Low-Birth-Weight Infant Born at 32 Weeks of Gestation: A Case Report.Cureus · 2025Article
- Extending Peripheral Retinal Vascularization in Retinopathy of Prematurity Through Regulation of VEGF Signaling.American journal of ophthalmology · 2024Article
- Pathophysiology of Retinopathy of Prematurity.Annual review of vision science · 2023Review
- Systemic Cytokines in Retinopathy of Prematurity.Journal of personalized medicine · 2023Review
- Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies?Pflugers Archiv : European journal of physiology · 2022Review
- Retinopathy of prematurity: contribution of inflammatory and genetic factors.Molecular and cellular biochemistry · 2022Review
- Retinopathy of Prematurity: Advances in the Screening and Treatment of Retinopathy of Prematurity Using a Single Center Approach.American journal of ophthalmology · 2022Article
- Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017.Acta ophthalmologica · 2021Article
- Frequency of retinopathy of prematurity (ROP) in infants screened for ROP: two years follow-up results of a single center in Turkey.BioMedicine · 2021Article
- Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia.Journal of lung, pulmonary & respiratory research · 2020Article
- Surgical outcomes of microincision vitrectomy surgery in eyes with retinal detachment secondary to retinopathy of prematurity in Indian population.Indian journal of ophthalmology · 2019Article
- The ROPScore as a Screening Algorithm for Predicting Retinopathy of Prematurity in a Brazilian Population.Clinics (Sao Paulo, Brazil) · 2018Article
- Oxidative stress in the retina: implications for Retinopathy of Prematurity.Current opinion in toxicology · 2018Article
- Effects of LY294002 on the function of retinal endothelial cellInternational journal of ophthalmology · 2018Article
- Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.Biochimica et biophysica acta · 2016Article
- 17β-estradiol ameliorates oxygen-induced retinopathy in the early hyperoxic phase.Biochemical and biophysical research communications · 2015Article
- Pathophysiology and mechanisms of severe retinopathy of prematurity.Ophthalmology · 2015Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purposeTo study vascular endothelial growth factor (VEGF) regulation in the development of intravitreous neovascularization and peripheral avascular retina in peripheral severe retinopathy of prematurity (ROP).
methodsThe rat 50/10 model of ROP mimics zone II, stage 3 severe ROP and recreates fluctuations in transcutaneous oxygen levels in preterm infants. On postnatal (p) day ages p0, p8, p11-p14, and p18, retinas from the model or room-air (RA) age-matched pups were analyzed for mRNA of VEGF splice variants and receptors using real-time polymerase chain reaction or VEGF protein using enzyme-linked immunosorbent assay.
resultsOn p14, when retinas were only 70% vascularized in the model but fully vascularized in RA, VEGF₁₆₄ expression was threefold greater in the model compared to RA. On p18, intravitreous neovascularization was associated with a 5-fold increase in VEGF₁₆₄ mRNA in the model compared to RA. By analysis of variance, VEGF₁₆₄ and VEGFR2 mRNAs were up-regulated in association with increasing developmental age (P<.0001 for both comparisons) or exposure to the model compared to RA (P<.0001 and P=.0247, respectively), whereas increasing developmental age was associated only with up-regulated VEGF₁₂₀ (P=.0006), VEGF₁₈₈ (P=.0256), and VEGFR1 (P<.0001) mRNAs. VEGF protein increased significantly in the model and on p14 and p18 compared to RA (P<.0001).
conclusionsThe model mimics contemporary severe ROP in the United States unlike other models of oxygen-induced retinopathy. Compared to RA retinas, VEGF significantly increased in association with avascular retina and intravitreous neovascularization. A hypothesis is proposed that VEGF up-regulation plays a role in the development of both important features.
Indexed as
Identifiers
21212851PMC3016082W2153412164What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.