Evidence map›Paper›PMID 21212429›Full record

SynthesisThe oncologist2011

Effect of exercise training on peak oxygen consumption in patients with cancer: a meta-analysis.

Lee W Jones, Yuanyuan Liang, Edith N Pituskin, Claudio L Battaglini, Jessica M Scott, Whitney E Hornsby, Mark Haykowsky

Erratum issued 4 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The oncologist, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 4 registered trials, which are not on this map. Cited by 126 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03423056 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Efficacy and Safety of a Preoperative Aerobic Exercise Program in Patients With Gastrointestinal Cancer. A Phase II Clinical Trial

TypeinterventionalSponsorInstituto Nacional de Cancerologia, ColumbiaRan2017 to 2019Enrolled40ConditionsStomach Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Liver NeoplasmArmsPreoperative exercise program
NCT03860740 completednot on this mapstarted 2016, after this paper: background citation

Effect of Physical Exercise on Ki-67 Levels in Women With Operable Breast Cancer Hormonal Receptor Positive, HER2 Negative

TypeobservationalSponsorSpanish Breast Cancer Research GroupRan2016 to 2021Enrolled12ConditionsBreast Cancer, Luminal BArmsExercise, Stretching
NCT04467411 active not recruitingnot on this mapstarted 2020, after this paper: background citation

Randomised Controlled Study of Physical Exercise Intervention in Breast Cancer Patients at Risk of Anthracycline-induced Cardiomyopathy:The EMBRACE Study

TypeobservationalSponsorUniversity of AberdeenRan2020 to 2030Enrolled70ConditionsBreast Cancer
NCT05779670 recruitingnot on this mapstarted 2023, after this paper: background citation

Treatment Adherence to a Personalized Home Exercise Program in Patients With Bone Cancer Undergoing Lower Extremity Resection and Reconstruction

TypeobservationalSponsorIstituto Ortopedico RizzoliRan2023 to 2026Enrolled50ConditionsOsteosarcoma, Ewing Sarcoma, Chondrosarcoma, Bone Tumor
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  7. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
    Pooled it
  8. Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  9. Physical activity programming and counseling preferences among cancer survivors: a systematic review.The international journal of behavioral nutrition and physical activity · 2018
    Pooled it
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  11. The effect of physical activity on fatigue among survivors of colorectal cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
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  13. Determinants of exercise adherence and maintenance among cancer survivors: a systematic review.The international journal of behavioral nutrition and physical activity · 2014
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

7 authors.

Lee W JonesBox 3085, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA. lee.w.jones@duke.edu
Yuanyuan Liang
Edith N Pituskin
Claudio L Battaglini
Jessica M Scott
Whitney E Hornsby
Mark Haykowsky

Funding

Randomized Trial of Optimal Type of Aerobic Training in Breast CancerR01CA142566 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JONES, LEE W · 2010 to 2017
$2.7M
Synergistically Acting Targeted Therapeutics for MelanomaR01CA138634 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ROBERTSON, GAVIN P. · 2010 to 2014
$1.5M
Phase II Trial of Aerobic Training in Metastatic Breast CancerR21CA143254 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JONES, LEE W · 2010 to 2012
$536k
Exercise Training, Erectile Dysfunction, and Prostate CancerR21CA133895 · NCI · DUKE UNIVERSITY · PI JONES, LEE W · 2009 to 2011
$503k
Using Message Framing to Promote Physical Activity in Colorectal Cancer SurvivorsR21CA125458 · NCI · DUKE UNIVERSITY · PI JONES, LEE W · 2008 to 2009
$421k
NCI NIH HHS CA125458NCI NIH HHS CA133895NCI NIH HHS CA138634NCI NIH HHS CA142566NCI NIH HHS CA143254NCI NIH HHS R01 CA138634NCI NIH HHS R01 CA142566NCI NIH HHS R21 CA125458NCI NIH HHS R21 CA133895NCI NIH HHS R21 CA143254
6 · The paper itself

Abstract

backgroundWe conducted a meta-analysis to determine the effects of supervised exercise training on peak oxygen consumption (VO(2peak)) in adults with cancer.

methodsA literature review using Ovid MEDLINE (1950-2010), the Cochrane Central Register of Controlled Trials (1991-2010), AMED (1985-2010), Embase (1988-2010), PubMed (1966-2010), Scopus (1950-2010), and Web of Science (1950-2010) was performed to identify randomized controlled trials examining the effects of supervised exercise training on measurement of VO(2peak) (via gas exchange analysis) in adults with cancer. Studies were selected using predetermined criteria, and two independent reviewers extracted data. Weighted mean differences (WMDs) were calculated using random effect models.

resultsSix studies evaluated VO(2peak) involving a total of 571 adult cancer patients (exercise, n = 344; usual care control, n = 227). Pooled data indicated that exercise training was associated with a statistically significant increase in VO(2peak) (WMD, 2.90 ml·kg(-1)·min(-1); 95% confidence interval [CI], 1.16-4.64); however, significant heterogeneity was evident in this estimate (I(2), 87%). Usual care (control) was associated with a significant decline in VO(2peak) from baseline to postintervention (WMD, -1.02 ml·kg(-1)·min(-1); 95% CI, -1.46 to -0.58; I(2), 22%). Sensitivity analyses indicated superior improvements in VO(2peak) for studies conducted for a shorter duration (<4 months) and following the completion of adjuvant therapy (p-values < .001). Exercise training was not associated with a higher incidence of adverse events, although safety was not rigorously monitored or reported.

conclusionsSupervised exercise training is associated with significant improvements in VO(2peak) following a diagnosis of early-stage cancer, with minimal adverse events.

Indexed as

AgedExerciseExercise TherapyFemaleHumansMaleMiddle AgedNeoplasmsOxygen ConsumptionRandomized Controlled Trials as Topic

Identifiers

PMID21212429
PMCPMC3228052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.