ReviewCirculation research2011
Whole-heart modeling: applications to cardiac electrophysiology and electromechanics.
Review in Circulation research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
155 citing papers in PubMed, 350 citations in OpenAlex.
- Trial
- Prediction of arrhythmogenesis in non-ischemic cardiac resynchronization therapy patients.APL bioengineering · 2026Article
- The Hodgkin-Huxley-Katz Prize Lecture: Heart digital twins: A new paradigm in arrhythmia medicine.The Journal of physiology · 2026Article
- Post-MI Remodeling Mechanics of Left Ventricle: Microstructure-Informed Models, Identifiability, and Uncertainty for Patient-Specific Prediction.Bioengineering (Basel, Switzerland) · 2026Review
- First Clinical Results of Novel Haemodynamic Simulation Software for Patient-Specific Qp:Qs Quantification in Patients with Atrial Septal Defect Using Routine 2D Echocardiographic Data.Journal of clinical medicine · 2026Article
- Three-dimensional visualization of arrhythmogenic substrate in mouse hearts using panoramic optical mapping and micro-computed tomography.Nature cardiovascular research · 2026Article
- Toward Standardized Methodologies for Drug-Induced Proarrhythmia Classification: An In Silico Proof of Concept.Computational and structural biotechnology journal · 2026Article
- Asymmetric wall-stress heterogeneity defines a stretch-activated arrhythmogenic substrate beyond ejection fraction in dilated cardiomyopathy: an in silico study.Frontiers in physiology · 2026Article
- Physics-augmented Multi-task Gaussian Process for Modeling Spatiotemporal Dynamics.IEEE transactions on automation science and engineering : a publication of the IEEE Robotics and Automation Society · 2026Article
- Self-organizing network simulation of cardiac contraction dynamics.Chaos (Woodbury, N.Y.) · 2025Article
- Developing cardiac biomechanical models beyond the clinic: modeling stressors of daily life.Biomechanics and modeling in mechanobiology · 2025Review
- Article
- Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts.Journal of visualized experiments : JoVE · 2025Article
- Advanced Cardiovascular Toxicity Screening: Integrating Human iPSC-Derived Cardiomyocytes with 2D In Silico Models.Cardiovascular toxicology · 2025Article
- Self-organizing network simulation of cardiac electrical dynamics.Chaos (Woodbury, N.Y.) · 2025Article
- Ultrastructure and cardiac impulse propagation: scaling up from microscopic to macroscopic conduction.The Journal of physiology · 2025Review
- A personalized time-resolved 3D mesh generative model for unveiling normal heart dynamics.Nature machine intelligence · 2025Article
- Self-organizing network representation of human heart.Chaos (Woodbury, N.Y.) · 2024Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- The role of computational methods in cardiovascular medicine: a narrative review.Translational pediatrics · 2024Review
95 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recent developments in cardiac simulation have rendered the heart the most highly integrated example of a virtual organ. We are on the brink of a revolution in cardiac research, one in which computational modeling of proteins, cells, tissues, and the organ permit linking genomic and proteomic information to the integrated organ behavior, in the quest for a quantitative understanding of the functioning of the heart in health and disease. The goal of this review is to assess the existing state-of-the-art in whole-heart modeling and the plethora of its applications in cardiac research. General whole-heart modeling approaches are presented, and the applications of whole-heart models in cardiac electrophysiology and electromechanics research are reviewed. The article showcases the contributions that whole-heart modeling and simulation have made to our understanding of the functioning of the heart. A summary of the future developments envisioned for the field of cardiac simulation and modeling is also presented. Biophysically based computational modeling of the heart, applied to human heart physiology and the diagnosis and treatment of cardiac disease, has the potential to dramatically change 21st century cardiac research and the field of cardiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.