ArticleProceedings of the National Academy of Sciences of the United States of America2011
Birth and death of genes linked to chromosomal inversion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 69 citations in OpenAlex.
- Global diversity of integrating conjugative elements (ICEs) inbioRxiv : the preprint server for biology · 2025Article
- Chromosomal Inversions Mediated by Tandem Insertions of Transposable Elements.Genome biology and evolution · 2025Article
- Group B streptococcus virulence factors associated with different clinical syndromes: Asymptomatic carriage in pregnant women and early-onset disease in the newborn.Frontiers in microbiology · 2023Article
- Pangenome Evolution in Environmentally Transmitted Symbionts of Deep-Sea Mussels Is Governed by Vertical Inheritance.Genome biology and evolution · 2022Article
- Recurrent chromosome reshuffling and the evolution of neo-sex chromosomes in parrots.Nature communications · 2022Article
- Different Regulatory Strategies of Arsenite Oxidation by Two IsolatedFrontiers in microbiology · 2022Article
- Geographic diversity in Helicobacter pylori oipA genotype between Korean and United States isolates.Journal of microbiology (Seoul, Korea) · 2021Article
- Article
- Outer inflammatory protein of Helicobacter pylori impacts IL-8 expression, adherence, cell apoptosis and cell cycle of gastric cells independent of its copy number.Medical microbiology and immunology · 2020Article
- Some of the Factors Involved in Male Infertility: A Prospective Review.International journal of general medicine · 2020Review
- Rearrangement analysis of multiple bacterial genomes.BMC bioinformatics · 2019Article
- Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori.Scientific reports · 2019Article
- The Genomic Complexity of a Large Inversion in Great Tits.Genome biology and evolution · 2019Article
- A SystematicCurrent genomics · 2017Article
- A Locus Encoding Variable Defense Systems against Invading DNA Identified in Streptococcus suis.Genome biology and evolution · 2017Article
- Dynamic Expansion and Contraction ofmBio · 2017Article
- Restriction-Modification Systems as Mobile Genetic Elements in the Evolution of an Intracellular Symbiont.Molecular biology and evolution · 2016Article
- A Novel Approach to Helicobacter pylori Pan-Genome Analysis for Identification of Genomic Islands.PloS one · 2016Article
- Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization.PLoS pathogens · 2015Article
- Transmission of the PabI family of restriction DNA glycosylase genes: mobility and long-term inheritance.BMC genomics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The birth and death of genes is central to adaptive evolution, yet the underlying genome dynamics remain elusive. The availability of closely related complete genome sequences helps to follow changes in gene contents and clarify their relationship to overall genome organization. Helicobacter pylori, bacteria in our stomach, are known for their extreme genome plasticity through mutation and recombination and will make a good target for such an analysis. In comparing their complete genome sequences, we found that gain and loss of genes (loci) for outer membrane proteins, which mediate host interaction, occurred at breakpoints of chromosomal inversions. Sequence comparison there revealed a unique mechanism of DNA duplication: DNA duplication associated with inversion. In this process, a DNA segment at one chromosomal locus is copied and inserted, in an inverted orientation, into a distant locus on the same chromosome, while the entire region between these two loci is also inverted. Recognition of this and three more inversion modes, which occur through reciprocal recombination between long or short sequence similarity or adjacent to a mobile element, allowed reconstruction of synteny evolution through inversion events in this species. These results will guide the interpretation of extensive DNA sequencing results for understanding long- and short-term genome evolution in various organisms and in cancer cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.