ReviewJournal of applied physiology (Bethesda, Md. : 1985)2011
Lung tissue mechanics as an emergent phenomenon.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
71 citing papers in PubMed, 153 citations in OpenAlex.
- Stochastic Resonance Effects on Apnea, Bradycardia, and Oxygenation: A Randomized Controlled Trial.Pediatrics · 2015Trial
- A Systematic Study of GelMA-Carbopol Bioinks for High-Fidelity Extrusion 3D Bioprinting at Physiological Temperatures.Advanced healthcare materials · 2026Article
- Mechanical stress promotes excessive NETs and exacerbates acute lung injury via Piezo1-mediated mitochondrial dysfunction.Redox biology · 2026Article
- Cooperation, Defection, and Collapse: A Multiscale Game Theory Framework for Emphysema Progression.Cells · 2026Review
- Global Research Trends in Forced Oscillation Technique (FOT) and Impulse Oscillometry System (IOS): A Bibliometric Analysis of Impact and Emerging Areas.Healthcare (Basel, Switzerland) · 2026Review
- Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function.bioRxiv : the preprint server for biology · 2026Article
- A multi-fidelity poroelastic finite element and machine learning framework for characterizing respiratory mechanics in porcine lungs.Biomechanics and modeling in mechanobiology · 2026Article
- The lung in acute respiratory failure: insights from synchrotron radiation imaging.Intensive care medicine experimental · 2026Review
- Regenerative therapeutics for chronic obstructive pulmonary disease.Pharmacological reviews · 2026Review
- Biomechanical characterization of human lung bullae using uniaxial tensile tests and CT-derived geometry-specific finite element analysis.Frontiers in physiology · 2026Article
- Impact of physiological strain on lung epithelial cells by exposure to aerosolised quartz silica in a perfused bioreactor.Frontiers in bioengineering and biotechnology · 2026Article
- A Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation.Advances in experimental medicine and biology · 2026Review
- Beyond the Critical Threshold: Elastic Fiber Remodeling and Fracture in the Pathogenesis of Pulmonary Emphysema.International journal of molecular sciences · 2025Review
- Pulmonary Biomechanics in COPD: Imaging Techniques and Clinical Applications.Journal of biomechanical engineering · 2025Review
- Rodent Models of Lung Disease: A Road Map for Translational Research.International journal of molecular sciences · 2025Review
- Nanoscale structural alteration of lung collagen in response to strain and bleomycin injury.Scientific reports · 2025Article
- Fibrotic and emphysematous murine lung mechanics under negative-pressure ventilation.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Desmosine: The Rationale for Its Use as a Biomarker of Therapeutic Efficacy in the Treatment of Pulmonary Emphysema.Diagnostics (Basel, Switzerland) · 2025Article
- Elastin Peptides as a Potential Disease Vector in the Pathogenesis of Pulmonary Emphysema: An Investigation of This Hypothesis.Life (Basel, Switzerland) · 2025Article
- Micromechanics of lung capillaries across mouse lifespan and in positive- vs negative-pressure ventilation.npj biological physics and mechanics · 2025Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanical properties of lung parenchymal tissue are both elastic and dissipative, as well as being highly nonlinear. These properties cannot be fully understood, however, in terms of the individual constituents of the tissue. Rather, the mechanical behavior of lung tissue emerges as a macroscopic phenomenon from the interactions of its microscopic components in a way that is neither intuitive nor easily understood. In this review, we first consider the quasi-static mechanical behavior of lung tissue and discuss computational models that show how smooth nonlinear stress-strain behavior can arise through a percolation-like process in which the sequential recruitment of collagen fibers with increasing strain causes them to progressively take over the load-bearing role from elastin. We also show how the concept of percolation can be used to link the pathologic progression of parenchymal disease at the micro scale to physiological symptoms at the macro scale. We then examine the dynamic mechanical behavior of lung tissue, which invokes the notion of tissue resistance. Although usually modeled phenomenologically in terms of collections of springs and dashpots, lung tissue viscoelasticity again can be seen to reflect various types of complex dynamic interactions at the molecular level. Finally, we discuss the inevitability of why lung tissue mechanics need to be complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.