ArticleThe Biochemical journal1990
Purification of a high-molecular-mass form of phospholipase A2 from rat kidney activated at physiological calcium concentrations.
Article in The Biochemical journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 172 citations in OpenAlex.
- Eicosanoids in Cancer: New Roles in Immunoregulation.Frontiers in pharmacology · 2020Review
- Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.Journal of ethnopharmacology · 2018Article
- Cytosolic phospholipase A₂: physiological function and role in disease.Journal of lipid research · 2015Review
- Group IVA phospholipase A₂ optimizes ovulation and fertilization in rodents through induction of and metabolic coupling with prostaglandin endoperoxide synthase 2.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Cytosolic phospholipase A(2) regulates golgi structure and modulates intracellular trafficking of membrane proteins.The Journal of clinical investigation · 2000Article
- Phospholipases A2 in ischemic and toxic brain injury.Neurochemical research · 2000Review
- Extracellular calcium regulates HeLa cell morphology during adhesion to gelatin: role of translocation and phosphorylation of cytosolic phospholipase A2.Molecular biology of the cell · 1998Article
- Role of G-protein beta gamma subunits in the augmentation of P2Y2 (P2U)receptor-stimulated responses by neuropeptide Y Y1 Gi/o-coupled receptors.The Biochemical journal · 1997Article
- Suppression of smooth-muscle alpha-actin expression by platelet-derived growth factor in vascular smooth-muscle cells involves Ras and cytosolic phospholipase A2.The Biochemical journal · 1997Article
- Hypercalcemia stimulates expression of intrarenal phospholipase A2 and prostaglandin H synthase-2 in rats. Role of angiotensin II AT1 receptors.The Journal of clinical investigation · 1997Article
- Multiple C-terminal serine phosphorylation accompanies both protein kinase C-dependent and -independent activation of cytosolic 85 kDa phospholipase A2 in macrophages.The Biochemical journal · 1997Article
- Sterol and steryl ester regulation of phospholipase A2 from the mosquito parasite Lagenidium giganteum.Lipids · 1996Article
- Role of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages: regulation by Ca2+ and phosphorylation.The Biochemical journal · 1995Article
- Roles of arachidonic acid, lipoxygenases and phosphatases in calcium-dependent modulation of M-current in bullfrog sympathetic neurons.The Journal of physiology · 1995Article
- Regulation of arachidonic acid, eicosanoid, and phospholipase A2 levels in murine mast cells by recombinant stem cell factor.The Journal of clinical investigation · 1995Article
- Leukotriene synthesis in calcium-depleted human neutrophils: arachidonic acid release correlates with calcium influx.The Biochemical journal · 1995Article
- Glutamate stably enhances the activity of two cytosolic forms of phospholipase A2 in brain cortical cultures.The Biochemical journal · 1995Article
- Transmembrane signaling in kidney health and disease.Pediatric nephrology (Berlin, Germany) · 1995Review
- Phospholipase A2 from plasma of patients with septic shock is associated with high-density lipoproteins and C3 anaphylatoxin: some implications for its functional role.The Biochemical journal · 1995Article
- Platelet-activating factor: the biosynthetic and catabolic enzymes.The Biochemical journal · 1995Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rat kidney contains a soluble phospholipase A2 (PLA2), which is chromatographically identical with a previously identified hormonally regulated form of the enzyme in rat renal mesangial cells. This kidney enzyme has been purified by sequential column fractionation. The purified enzyme is a 110 kDa polypeptide which can hydrolyse arachidonoyl phosphatidylcholine and arachidonoyl phosphatidylethanolamine, but has low activity towards arachidonoyl phosphatidylinositol. The enzyme is considerably larger than most previously isolated forms of secretory or intracellular PLA2, and is stimulated by physiological concentrations of Ca2+, with half-maximal activation occurring at 500 nM-Ca2+. The hormonal regulation and Ca2(+)-dependency of this enzyme strongly suggest that it plays a role in hormonally regulated arachidonic acid release and prostaglandin production in the kidney.
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Registered trials
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