Evidence map›Paper›PMID 21210759›Full record

ReviewTissue engineering. Part B, Reviews2011

Polyelectrolyte multilayers in tissue engineering.

Christopher J Detzel, Adam L Larkin, Padmavathy Rajagopalan

Abstract readReview
In one paragraph

Review in Tissue engineering. Part B, Reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher J DetzelDepartment of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Adam L Larkin
Padmavathy Rajagopalan

Funding

Three Dimensional In Vitro Liver Sinusoids: Design and Detoxification StudiesR21DK077802 · NIDDK · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI RAJAGOPALAN, PADMAVATHY · 2009 to 2010
$419k
NIDDK NIH HHS 1R21DK077802
6 · The paper itself

Abstract

The layer-by-layer assembly of sequentially adsorbed, alternating polyelectrolytes has become increasingly important over the past two decades. The ease and versatility in assembling polyelectrolyte multilayers (PEMs) has resulted in numerous wide ranging applications of these materials. More recently, PEMs are being used in biological applications ranging from biomaterials, tissue engineering, regenerative medicine, and drug delivery. The ability to manipulate the chemical, physical, surface, and topographical properties of these multilayer architectures by simply changing the pH, ionic strength, thickness, and postassembly modifications render them highly suitable to probe the effects of external stimuli on cellular responsiveness. In the field of regenerative medicine, the ability to sequester growth factors and to tether peptides to PEMs has been exploited to direct the lineage of progenitor cells and to subsequently maintain a desired phenotype. Additional novel applications include the use of PEMs in the assembly of three-dimensional layered architectures and as coatings for individual cells to deliver tunable payloads of drugs or bioactive molecules. This review focuses on literature related to the modulation of chemical and physical properties of PEMs for tissue engineering applications and recent research efforts in maintaining and directing cellular phenotype in stem cell differentiation.

Indexed as

AnimalsBiocompatible MaterialsCell DifferentiationCross-Linking ReagentsElasticityElectrolytesHumansHydrogen-Ion ConcentrationIonsPhenotypeRegenerative MedicineSurface PropertiesTissue EngineeringBiocompatible MaterialsCross-Linking ReagentsElectrolytesIons

Identifiers

PMID21210759
PMCPMC3062467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.