ReviewJournal of autism and developmental disorders2011
Brief report: "allergic symptoms" in children with Autism Spectrum Disorders. More than meets the eye?
Review in Journal of autism and developmental disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bibliometric study of neuroinflammation in autism spectrum disorder.Frontiers in psychiatry · 2023Pooled it
- Association of food hypersensitivity in children with the risk of autism spectrum disorder: a meta-analysis.European journal of pediatrics · 2021Pooled it
- Efficacy of olopatadine hydrochloride 0.1%, emedastine difumarate 0.05%, and loteprednol etabonate 0.5% for Chinese children with seasonal allergic conjunctivitis: a randomized vehicle-controlled study.International forum of allergy & rhinology · 2017Trial
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- Mast Cells in Autism Spectrum Disorder-The Enigma to Be Solved?International journal of molecular sciences · 2024Review
- Mast Cell Cytokines in Acute and Chronic Gingival Tissue Inflammation: Role of IL-33 and IL-37.International journal of molecular sciences · 2022Review
- Emergency Department Utilization of Adolescents and Young Adults with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Article
- Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, including Response to SARS-CoV-2, in Autism Spectrum Disorder.Journal of personalized medicine · 2021Review
- Bridging the Gap Between Physical Health and Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2020Review
- Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development.Autism research : official journal of the International Society for Autism Research · 2019Article
- Effects of CBD-EnrichedFrontiers in neurology · 2019Article
- Microglia M2A Polarization as Potential Link between Food Allergy and Autism Spectrum Disorders.Pharmaceuticals (Basel, Switzerland) · 2017Review
- Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers.Metabolic brain disease · 2017Article
- Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study.PloS one · 2017Article
- Observational
- Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders.Cellular and molecular life sciences : CMLS · 2016Review
- Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders.Translational psychiatry · 2016Review
- Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6.Translational psychiatry · 2015Article
- Brief report: Emergency department utilization by individuals with autism.Journal of autism and developmental disorders · 2015Article
- Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.Microbial ecology in health and disease · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of "allergic symptomatology", often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation.
Indexed as
Identifiers
21210299What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.