ArticlePathology oncology research : POR2011
Identification of signature genes for detecting hedgehog pathway activation in esophageal cancer.
Article in Pathology oncology research : POR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- An analysis about heterogeneity among cancers based on the DNA methylation patterns.BMC cancer · 2019Article
- The targeted regulation of Gli1 by miR-361 to inhibit epithelia-mesenchymal transition and invasion of esophageal carcinoma cells.Cancer biomarkers : section A of Disease markers · 2018Article
- Hedgehog Interacting Protein 1 is a Prognostic Marker and Suppresses Cell Metastasis in Gastric Cancer.Journal of Cancer · 2018Article
- The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons.Nucleic acids research · 2012Article
- Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus.International journal of biochemistry and molecular biology · 2012Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The hedgehog signaling pathway plays an important role in cell growth and differentiation both in normal embryonic development and in tumors. Our previous work shows that hedgehog pathway is frequently activated in esophageal cancers. To further elucidate the role of hedgehog pathway in esophageal cancers we examined the expression of the target genes, hedgehog-interacting protein (HIP) and platelet derived growth factor receptor alpha (PDGFRα) and hedgehog signaling molecules, smoothened (SMO), suppressor of fused (Su(Fu)) in the specimens using in-situ hybridization and RT-PCR. We found that HIP, PDGFRα, SMO and Su(Fu) gene highly expressed in the primary esophageal squamous cell carcinomas but not in normal esophageal tissue. The transcripts of HIP, PDGFRα and SMO were expressed in 13 of 15 esophageal cancers. Su(Fu) expression was missing in 2 esophageal cancers. The results from in-situ hybridization were further confirmed by RT-PCR. Our results revealed a set of genes for detecting hedgehog signaling activation in esophageal cancer.
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