ReviewEcotoxicology (London, England)2011
The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review.
Review in Ecotoxicology (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 227 citations in OpenAlex.
- Assessment of two minimally invasive methodologies for sex identification in the European eel, Anguilla anguilla.Journal of fish biology · 2026Article
- Assessment of the fish tumors or other deformities beneficial use impairment and associated risks at two Lake Michigan Areas of Concern.Ecotoxicology (London, England) · 2026Article
- Integrated Use of Oxidative Stress and Histological Biomarkers of T. tinca as Indicators of 17-Alpha-Ethynylestradiol Exposure.Environmental toxicology · 2026Article
- Enhancing Nonylphenol Biodegradation: The Role of Acetyl-CoA C-Acetyltransferase inBiotech (Basel (Switzerland)) · 2025Article
- Article
- Pharmaceuticals and Microplastics in Aquatic Environments: A Comprehensive Review of Pathways and Distribution, Toxicological and Ecological Effects.International journal of environmental research and public health · 2025Review
- Modulation of immune gene expression profile in Labeo catla with chronic toxicity to emerging endocrine disruptors through a multiorgan approach.Scientific reports · 2025Article
- Fishy factors: recognizing biological variation and its implications for fish immuno(eco)toxicology research.Environmental toxicology and chemistry · 2025Article
- Effects of dietary garlic (Allium sativum) oil on growth performance, haemato-biochemical and histopathology of cypermethrin-intoxicated Nile tilapia (Oreochromis niloticus).Veterinary medicine and science · 2024Article
- A Comparative Multi-System Approach to Characterizing Bioactivity of Commonly Occurring Chemicals.International journal of environmental research and public health · 2022Article
- Transcriptional Signatures of Immune, Neural, and Endocrine Functions in the Brain and Kidney of Rainbow Trout (International journal of molecular sciences · 2022Article
- Bisphenol A Induces Histopathological, Hematobiochemical Alterations, Oxidative Stress, and Genotoxicity in Common Carp (Oxidative medicine and cellular longevity · 2022Article
- Sex-specific elemental accumulation and histopathology of pikeperch (Sander lucioperca) from Garaši reservoir (Serbia) with human health risk assessment.Environmental science and pollution research international · 2021Article
- Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?International journal of molecular sciences · 2021Review
- Evaluation of an in vitro assay to screen for the immunotoxic potential of chemicals to fish.Scientific reports · 2021Article
- The intersection of stress, sex and immunity in fishes.Immunogenetics · 2021Review
- Modeling estrogenic activity in streams throughout the Potomac and Chesapeake Bay watersheds.Environmental monitoring and assessment · 2021Article
- Sex-specific differences in swimming, aerobic metabolism and recovery from exercise in adult coho salmon (Conservation physiology · 2021Article
- Steroid hormones and estrogenic activity in the wastewater outfall and receiving waters of the Chascomús chained shallow lakes system (Argentina).The Science of the total environment · 2020Article
- Histological Evaluation of Gonad Impairments in Russian Sturgeon (Animals : an open access journal from MDPI · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last decade, a number of studies have shown that, in addition to their classically described reproductive function, estrogens and androgens also regulate the immune system in teleosts. Today, several molecules are known to interfere with the sex-steroid signaling. These chemicals are often referred to as endocrine disrupting contaminants (EDCs). We review the growing evidence that these compounds interfere with the fish immune system. These studies encompass a broad range of approaches from field studies to those at the molecular level. This integrative overview improves our understanding of the various endocrine-disrupting processes triggered by these chemicals. Furthermore, the research also explains why fish that have been exposed to EDCs are more sensitive to pathogens during gametogenesis. In this review, we first discuss the primary actions of sex-steroid-like endocrine disruptors in fish and the specificity of the fish immune system in comparison to mammals. Then, we review the known interactions between the immune system and EDCs and interpret the primary effects of sex steroids (estrogens and androgens) and their related endocrine disruptors on immune modulation. The recent literature suggests that immune parameters may be used as biomarkers of contamination by EDCs. However, caution should be used in the assessment of such immunotoxicity. In particular, more attention should be paid to the specificity of these biomarkers, the external/internal factors influencing the response, and the transduction pathways induced by these molecules in fish. The use of the well-known mammalian models provides a useful guide for future research in fish.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.