ArticleIntensive care medicine2011
The metrics of glycaemic control in critical care.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.Intensive care medicine · 2013Guideline
- Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients.Critical care (London, England) · 2015Trial
- Tight computerized versus conventional glucose control in the ICU: a randomized controlled trial.Intensive care medicine · 2014Trial
- Glycemic variability and glucose complexity in critically ill patients: a retrospective analysis of continuous glucose monitoring data.Critical care (London, England) · 2012Trial
- Accuracy of continuous glucose monitoring in critically ill patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Utility of bedside artificial pancreas for postoperative glycemic control in cardiac surgery.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021Article
- Study protocol and statistical analysis plan for the Liberal Glucose Control in Critically Ill Patients with Pre-existing Type 2 Diabetes (LUCID) trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020Article
- Dynamic properties of glucose complexity during the course of critical illness: a pilot study.Journal of clinical monitoring and computing · 2020Observational
- Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients: A prospective cohort study.PloS one · 2018Article
- Comparative Simulation Study of Glucose Control Methods Designed for Use in the Intensive Care Unit Setting via a Novel Controller Scoring Metric.Journal of diabetes science and technology · 2017Article
- Article
- Glucose Control in the ICU: A Continuing Story.Journal of diabetes science and technology · 2016Review
- Current topics in glycemic control by wearable artificial pancreas or bedside artificial pancreas with closed-loop system.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2016Review
- Associations between bolus infusion of hydrocortisone, glycemic variability and insulin infusion rate variability in critically Ill patients under moderate glycemic control.Annals of intensive care · 2015Article
- Hemoglobin Area and Time Index Above 90 g/L are Associated with Improved 6-Month Functional Outcomes in Patients with Severe Traumatic Brain Injury.Neurocritical care · 2015Article
- Reporting on Glucose Control Metrics in the Intensive Care Unit.European endocrinology · 2015Review
- The Development of a Continuous Intravascular Glucose Monitoring Sensor.Journal of diabetes science and technology · 2015Article
- Hyperglycemia in Critically Ill Patients: Management and Prognosis.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2015Observational
- Year in review 2013: Critical Care--metabolism.Critical care (London, England) · 2014Review
- Blood glucose level and outcome after cardiac arrest: insights from a large registry in the hypothermia era.Intensive care medicine · 2014Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTrials of tight glucose control have compared measures of central tendency, such as average blood glucose, and yielded conflicting results. Other metrics, such as standard deviation, reflect different properties of glucose control and are also associated with changes in outcome. It is possible, therefore, that the conflicting results from interventional studies arise from effects on glycaemic control that have not been reported.
methodsUsing glucose measurements from patients admitted to four adult intensive care units in one UK hospital, we sought to identify metrics of glycaemic control, examine the relationship between them and identify the metrics that are both independently and most strongly associated with outcome.
resultsWe examined nine previously described metrics and identified a further four. Cluster analysis classified these metrics into two families, namely, those reflecting measures of central tendency and those reflecting measures of dispersion. A measure of minimum glucose was also identified but related to neither family. Plots of the quintiles of these metrics against hospital mortality revealed population-specific relationships. Areas under receiver-operating characteristic curves could not identify an optimum metric of central tendency or dispersion. Using odds ratios, we were able to show that the effect of these metrics is independent of one another.
conclusionOur results suggest that glycaemic control is associated with outcome on the basis of three independent metrics, reflecting measures of central tendency, measures of dispersion and a measure of minimum glucose.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.