ArticlePloS one2010
Mammalian stem cells reprogramming in response to terahertz radiation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Non-Thermal Effects of Terahertz Radiation on Gene Expression: Systematic Review and Meta-Analysis.Genes · 2024Pooled it
- 3.75 THz Repetitive Radiation Regulates Collagen Metabolism in Human Fetal Scleral Fibroblasts.Cells · 2026Article
- Terahertz Modulation of Biomolecular Dynamics: Physical Mechanisms, Biological Implications, and Future Challenges.Research (Washington, D.C.) · 2026Review
- Response of pheochromocytoma neuronal cells to varying intensity of continuous wave terahertz radiation.Journal of synchrotron radiation · 2025Article
- Protocol for simulating the effect of THz electromagnetic field on ion channels.Quantitative biology (Beijing, China) · 2025Article
- Effect of terahertz radiation on cells and cellular structures.Frontiers of optoelectronics · 2025Review
- Molecular dynamics simulation in tissue engineering.BioImpacts : BI · 2025Review
- The Transcriptomic Response of Cells of the Thermophilic BacteriumInternational journal of molecular sciences · 2024Article
- Examining DNA breathing with pyDNA-EPBD.Bioinformatics (Oxford, England) · 2023Article
- The biological effects of terahertz wave radiation-induced injury on neural stem cells.iScience · 2023Article
- Spectral Characteristics and Functional Responses of Phospholipid Bilayers in the Terahertz Band.International journal of molecular sciences · 2023Article
- Specific Features of the Proteomic Response of Thermophilic BacteriumInternational journal of molecular sciences · 2022Article
- Towards super-resolved terahertz microscopy for cellular imaging.Journal of microscopy · 2022Review
- Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases.Journal of biomedical science · 2022Review
- A Comparative Study on the Viability of Normal and Cancerous Cells upon Irradiation with a Steady Beam of THz Rays.Life (Basel, Switzerland) · 2022Article
- Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiationiScience · 2021Article
- Cellular effects of terahertz waves.Journal of biomedical optics · 2021Review
- 0.1 THz exposure affects primary hippocampus neuron gene expression via alternating transcription factor binding.Biomedical optics express · 2021Article
- Research progress in the effects of terahertz waves on biomacromolecules.Military Medical Research · 2021Review
- Terahertz pulses induce segment renewal via cell proliferation and differentiation overriding the endogenous regeneration program of the earthwormBiomedical optics express · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
We report that extended exposure to broad-spectrum terahertz radiation results in specific changes in cellular functions that are closely related to DNA-directed gene transcription. Our gene chip survey of gene expression shows that whereas 89% of the protein coding genes in mouse stem cells do not respond to the applied terahertz radiation, certain genes are activated, while other are repressed. RT-PCR experiments with selected gene probes corresponding to transcripts in the three groups of genes detail the gene specific effect. The response was not only gene specific but also irradiation conditions dependent. Our findings suggest that the applied terahertz irradiation accelerates cell differentiation toward adipose phenotype by activating the transcription factor peroxisome proliferator-activated receptor gamma (PPARG). Finally, our molecular dynamics computer simulations indicate that the local breathing dynamics of the PPARG promoter DNA coincides with the gene specific response to the THz radiation. We propose that THz radiation is a potential tool for cellular reprogramming.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.