Evidence map›Paper›PMID 21209782›Full record

ArticleCancer microenvironment : official journal of the International Cancer Microenvironment Society2010

A digest on the role of the tumor microenvironment in gastrointestinal cancers.

Martin Augsten, Christina Hägglöf, Cristina Peña, Arne Ostman

Open access · bronzeAbstract read
In one paragraph

Article in Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The emerging role of Snail1 in the tumor stroma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016
    Review
  6. Three-dimensional Co-culture model for tumor-stromal interaction.Journal of visualized experiments : JoVE · 2015
    Article
  7. Article
  8. Role of stromal-epithelial interaction in the formation and development of cancer cells.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013
    Article
  9. Article
  10. Article
  11. Tumor stroma as targets for cancer therapy.Pharmacology & therapeutics · 2013
    Review
  12. Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in ApcMin mouse model of colon cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Martin AugstenDepartment of Oncology-Pathology, Karolinska Institute, 171 76 Stockholm, Sweden.
Christina Hägglöf
Cristina Peña
Arne Ostman
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experimental studies and analyses of clinical material have convincingly demonstrated that tumor formation and progression occurs through a concerted action of malignant cells and the surrounding microenvironment of the tumor stroma. The tumor microenvironment is comprised of various cell types like fibroblasts, immune cells, vascular cells and bone-marrow-derived cells embedded in the extracellular matrix. This review, focusing on recent findings in the context of gastrointestinal tumors, introduces the different stromal cell types and delineates their contributions to cancer initiation, growth and metastasis. By selected examples we also present how the tumor microenvironment is emerging as a promising target for therapeutic intervention.

Indexed as

TherapyTumor microenvironmentTumor stroma

Identifiers

PMID21209782
PMCPMC2990496
OpenAlexW2172038052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.