ArticleCancer microenvironment : official journal of the International Cancer Microenvironment Society2010
A digest on the role of the tumor microenvironment in gastrointestinal cancers.
Article in Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Potential therapeutic targets of gastric cancer explored under endogenous network modeling of clinical data.Scientific reports · 2024Article
- [Exploration of the Perturbation of PKIG in Lung Squamous Cell Carcinoma and the Role in Tumor Microenvironment Based on Bioinformatics Method].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Article
- Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1.Oncogenesis · 2018Article
- Article
- The emerging role of Snail1 in the tumor stroma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Review
- Three-dimensional Co-culture model for tumor-stromal interaction.Journal of visualized experiments : JoVE · 2015Article
- Transcriptional coexpression network reveals the involvement of varying stem cell features with different dysregulations in different gastric cancer subtypes.Molecular oncology · 2014Article
- Role of stromal-epithelial interaction in the formation and development of cancer cells.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
- Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients.Cancer science · 2013Article
- A novel probe for the non-invasive detection of tumor-associated inflammation.Oncoimmunology · 2013Article
- Tumor stroma as targets for cancer therapy.Pharmacology & therapeutics · 2013Review
- Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in ApcMin mouse model of colon cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Tumor interstitial fluid and gastric cancer metastasis: an experimental study to verify the hypothesis of "tumor-phlegm microenvironment".Chinese journal of integrative medicine · 2012Article
- Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Targeting tumor microenvironment: the key role of immune system.BioImpacts : BI · 2012Article
- [Tumor microenvironment in gastrointestinal tumors].Der Pathologe · 2011Review
- Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment.Gastroenterology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental studies and analyses of clinical material have convincingly demonstrated that tumor formation and progression occurs through a concerted action of malignant cells and the surrounding microenvironment of the tumor stroma. The tumor microenvironment is comprised of various cell types like fibroblasts, immune cells, vascular cells and bone-marrow-derived cells embedded in the extracellular matrix. This review, focusing on recent findings in the context of gastrointestinal tumors, introduces the different stromal cell types and delineates their contributions to cancer initiation, growth and metastasis. By selected examples we also present how the tumor microenvironment is emerging as a promising target for therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.