ArticleCancer microenvironment : official journal of the International Cancer Microenvironment Society2010
The hemopoietic stem cell niche versus the microenvironment of the multiple myeloma-tumor initiating cell.
Article in Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Association of lipid levels, adipokines and multiple myeloma: a two-sample multivariate Mendelian randomization study.Scientific reports · 2024Article
- Review
- Measuring the global, regional, and national burden of multiple myeloma from 1990 to 2019.BMC cancer · 2021Article
- Multiple Myeloma as a Bone Disease? The Tissue Disruption-Induced Cell Stochasticity (TiDiS) Theory.Cancers · 2020Article
- Effects of triptolide on bone marrow-derived mesenchymal stem cells from patients with multiple myeloma.Experimental and therapeutic medicine · 2019Article
- A role for IL-34 in osteolytic disease of multiple myeloma.Blood advances · 2019Article
- The Role of Tumor Microenvironment in Genomic Instability of Malignant Tumors.Frontiers in genetics · 2019Review
- Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event.Frontiers in oncology · 2018Article
- Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Bone microenvironment-mediated resistance of cancer cells to bisphosphonates and impact on bone osteocytes/stem cells.Clinical & experimental metastasis · 2016Article
- Identify multiple myeloma stem cells: Utopia?World journal of stem cells · 2015Review
- High OCT4 and Low p16(INK4A) Expressions Determine In Vitro Lifespan of Mesenchymal Stem Cells.Stem cells international · 2015Article
- Immunological dysregulation in multiple myeloma microenvironment.BioMed research international · 2014Review
- Macrophages in multiple myeloma: emerging concepts and therapeutic implications.Leukemia & lymphoma · 2013Review
- Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells.Acta pharmacologica Sinica · 2013Article
- Targeting bone as a therapy for myeloma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011Article
- The origins of mesenchymal stromal cell heterogeneity.Stem cell reviews and reports · 2011Review
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Abstract
Multiple myeloma cells are reminiscent of hemopoietic stem cells in their strict dependence upon the bone marrow microenvironment. However, from all other points of view, multiple myeloma cells differ markedly from stem cells. The cells possess a mature phenotype and secrete antibodies, and have thus made the whole journey to maturity, while maintaining a tumor phenotype. Not much credence was given to the possibility that the bulk of plasma-like multiple myeloma tumor cells is generated from tumor-initiating cells. Although interleukin-6 is a major contributor to the formation of the tumor's microenvironment in multiple myeloma, it is not a major factor within hemopoietic stem cell niches. The bone marrow niche for myeloma cells includes the activity of inflammatory cytokines released through osteoclastogenesis. These permit maintenance of myeloma cells within the bone marrow. In contrast, osteoclastogenesis constitutes a signal that drives hemopoietic stem cells away from their bone marrow niches. The properties of the bone marrow microenvironment, which supports myeloma cell maintenance and proliferation, is therefore markedly different from the characteristics of the hemopoietic stem cell niche. Thus, multiple myeloma presents an example of a hemopoietic tumor microenvironment that does not resemble the corresponding stem cell renewal niche.
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