ArticlePloS one2010
A differential drug screen for compounds that select against antibiotic resistance.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Programming CRISPRi to control the lifecycle of bacteriophage T7.Frontiers in microbiology · 2025Article
- Collateral Sensitivity to β-Lactam Antibiotics in Evolved Apramycin-Resistant MRSA.International journal of molecular sciences · 2024Article
- Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials.Biomolecules · 2023Article
- Ribosome-binding antibiotics increase bacterial longevity and growth efficiency.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Collateral sensitivity profiling in drug-resistant Escherichia coli identifies natural products suppressing cephalosporin resistance.Nature communications · 2023Article
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- Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors.Nature communications · 2021Article
- Ubiquitous selection for mecA in community-associated MRSA across diverse chemical environments.Nature communications · 2020Article
- Diffusion-driven enhancement of the antibiotic resistance selection window.Journal of the Royal Society, Interface · 2019Article
- Removal ofMethodsX · 2019Article
- Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance.Molecular biology and evolution · 2018Article
- Macroscale fluorescence imaging against autofluorescence under ambient light.Light, science & applications · 2018Article
- Suppressive drug combinations and their potential to combat antibiotic resistance.The Journal of antibiotics · 2017Review
- Epistasis and the Evolution of Antimicrobial Resistance.Frontiers in microbiology · 2017Review
- Compounds that select against the tetracycline-resistance efflux pump.Nature chemical biology · 2016Article
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- Antibiotics: New recipe for targeting resistance.Nature chemical biology · 2016Article
- A competitive trade-off limits the selective advantage of increased antibiotic production.Nature microbiology · 2016Article
- Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments.Nature communications · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Antibiotics increase the frequency of resistant bacteria by providing them a competitive advantage over sensitive strains. Here, we develop a versatile assay for differential chemical inhibition of competing microbial strains, and use it to identify compounds that preferentially inhibit tetracycline-resistant relative to sensitive bacteria, thus "inverting" selection for resistance. Our assay distinguishes compounds selecting directly against specific resistance mechanisms and compounds whose selection against resistance is based on their physiological interaction with tetracycline and is more general with respect to resistance mechanism. A pilot screen indicates that both types of selection-inverting compounds are secreted by soil microbes, suggesting that nature has evolved a repertoire of chemicals that counteracts antibiotic resistance. Finally, we show that our assay can more generally permit simple, direct screening for drugs based on their differential activity against different strains or targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.