ArticleJournal of clinical microbiology2011
Distribution of putative virulence genes in Streptococcus mutans strains does not correlate with caries experience.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Strain-level genomic variation ofPeerJ · 2026Article
- Antibiofilm activity of Clitoria ternatea flowers anthocyanin fraction against biofilm-forming oral bacteria.FEMS microbiology letters · 2025Article
- Multilocus sequence typing and phenotypic properties of Streptococcus mutans from Thai children with different caries statuses.BMC oral health · 2024Article
- The Evolving Microbiome of Dental Caries.Microorganisms · 2024Review
- Effect of Different Cavity Disinfectants on Adhesion to Dentin of Permanent Teeth.Journal of functional biomaterials · 2022Article
- Article
- Genotypic and phenotypic characterization ofIranian journal of microbiology · 2021Article
- pH-Sensitive Chitosan Nanoparticles for Salivary Protein Delivery.Nanomaterials (Basel, Switzerland) · 2021Article
- Tetramic Acids Mutanocyclin and Reutericyclin A, Produced byFrontiers in oral health · 2021Article
- Composite Long- and Short-Read Sequencing Delivers a Complete Genome Sequence of B04Sm5, a Reutericyclin- and Mutanocyclin-Producing Strain of Streptococcus mutans.Microbiology resource announcements · 2020Article
- Gene expression of bacterial collagenolytic proteases in root caries.Journal of oral microbiology · 2018Article
- Exploring the Genomic Diversity and Cariogenic Differences of Streptococcus mutans Strains Through Pan-Genome and Comparative Genome Analysis.Current microbiology · 2017Article
- PlsX deletion impacts fatty acid synthesis and acid adaptation in Streptococcus mutans.Microbiology (Reading, England) · 2016Article
- [Dynamic changes of aciduric virulence factor membrane-bound proton-translocating ATPase of Streptococcus mutans in the development of dental caries].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2016Article
- Natural Immunoreactivity of Secretory IgA to Indigenous Strains of Streptococcus mutans From Chinese Spousal Pairs.Jundishapur journal of microbiology · 2016Article
- Oral Lactobacilli and Dental Caries: A Model for Niche Adaptation in Humans.Journal of dental research · 2015Review
- The usefulness of biotyping in the determination of selected pathogenicity determinants in Streptococcus mutans.BMC microbiology · 2014Article
- Comparative genomics of oral isolates of Streptococcus mutans by in silico genome subtraction does not reveal accessory DNA associated with severe early childhood caries.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Article
- Children with severe early childhood caries: streptococci genetic strains within carious and white spot lesions.Journal of oral microbiology · 2014Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Streptococcus mutans, a member of the human oral flora, is a widely recognized etiological agent of dental caries. The cariogenic potential of S. mutans is related to its ability to metabolize a wide variety of sugars, form a robust biofilm, produce copious amounts of lactic acid, and thrive in the acid environment that it generates. The remarkable genetic variability present within the species is reflected at the phenotypic level, notably in the differences in the cariogenic potential between strains. However, the genetic basis of these differences is yet to be elucidated. In this study, we surveyed by PCR and DNA hybridization the distribution of putative virulence genes, genomic islands, and insertion sequences across a collection of 33 strains isolated from either children with severe early childhood caries (S-ECC) or those who were caries free (CF). We found this genetically diverse group of isolates to be remarkably homogeneous with regard to the distribution of the putative virulence genes and genetic elements analyzed. Our findings point to the role of other factors in the pathogenesis of S-ECC, such as uncharacterized virulence genes, differences in gene expression and/or enzymatic activity, cooperation between S. mutans strains or with other members of the oral biota, and host factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.