ArticleJournal of virology2011
Identification and sequencing of a novel rodent gammaherpesvirus that establishes acute and latent infection in laboratory mice.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Mammal-infecting DNA viruses identified in lemurs and rodents in Madagascar mirror the evolutionary history of their hosts.Microbial genomics · 2026Article
- Herpesviruses: overview of systematics, genomic complexity and life cycle.Virology journal · 2025Review
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- Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses.Journal of virology · 2018Article
- Article
- Herpesviral capture of immunomodulatory host genes.Virus genes · 2017Review
- Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors.Structure (London, England : 1993) · 2016Article
- Detection of Murine Herpesvirus 68 (MHV-68) in Dermacentor reticulatus Ticks.Microbial ecology · 2015Article
- Convergent capture of retroviral superantigens by mammalian herpesviruses.Nature communications · 2015Article
- Kaposi's sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication.Journal of virology · 2014Article
- Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor.Journal of virology · 2014Article
- Identification of novel viruses using VirusHunter--an automated data analysis pipeline.PloS one · 2013Article
- Amplification of JNK signaling is necessary to complete the murine gammaherpesvirus 68 lytic replication cycle.Journal of virology · 2012Article
- Article
- A novel bat herpesvirus encodes homologues of major histocompatibility complex classes I and II, C-type lectin, and a unique family of immune-related genes.Journal of virology · 2012Article
- Newly discovered viral E3 ligase pK3 induces endoplasmic reticulum-associated degradation of class I major histocompatibility proteins and their membrane-bound chaperones.The Journal of biological chemistry · 2012Article
- Specific mutation of a gammaherpesvirus-expressed antigen in response to CD8 T cell selection in vivo.Journal of virology · 2012Article
- Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Gammaherpesviruses encode numerous immunomodulatory molecules that contribute to their ability to evade the host immune response and establish persistent, lifelong infections. As the human gammaherpesviruses are strictly species specific, small animal models of gammaherpesvirus infection, such as murine gammaherpesvirus 68 (γHV68) infection, are important for studying the roles of gammaherpesvirus immune evasion genes in in vivo infection and pathogenesis. We report here the genome sequence and characterization of a novel rodent gammaherpesvirus, designated rodent herpesvirus Peru (RHVP), that shares conserved genes and genome organization with γHV68 and the primate gammaherpesviruses but is phylogenetically distinct from γHV68. RHVP establishes acute and latent infection in laboratory mice. Additionally, RHVP contains multiple open reading frames (ORFs) not present in γHV68 that have sequence similarity to primate gammaherpesvirus immunomodulatory genes or cellular genes. These include ORFs with similarity to major histocompatibility complex class I (MHC-I), C-type lectins, and the mouse mammary tumor virus and herpesvirus saimiri superantigens. As these ORFs may function as immunomodulatory or virulence factors, RHVP presents new opportunities for the study of mechanisms of immune evasion by gammaherpesviruses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.