ArticleEndocrinology2011
Human endometrial cells express elevated levels of pluripotent factors and are more amenable to reprogramming into induced pluripotent stem cells.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Derivation of Granulosa-Like Cells from Human Endometrial iPSCs for Autologous Estradiol Production.Tissue engineering and regenerative medicine · 2025Article
- Human Endometrium Derived Induced Pluripotent Stem Cells Are Amenable to Directed Erythroid Differentiation.Tissue engineering and regenerative medicine · 2023Article
- Evaluating the effect of conditioned medium from endometrial stem cells on endometriosis-derived endometrial stem cells.Anatomy & cell biology · 2022Article
- Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments.International journal of medical sciences · 2021Review
- Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth.Scientific reports · 2018Article
- Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors.Stem cells international · 2018Review
- Eminent Sources of Adult Mesenchymal Stem Cells and Their Therapeutic Imminence.Stem cell reviews and reports · 2017Review
- Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients.Reproductive biology and endocrinology : RB&E · 2016Article
- Pluripotency Genes and Their Functions in the Normal and Aberrant Breast and Brain.International journal of molecular sciences · 2015Review
- Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease.Journal of cellular and molecular medicine · 2015Article
- Endometrial stem cells in regenerative medicine.Journal of biological engineering · 2014Review
- Induced pluripotency of human prostatic epithelial cells.PloS one · 2013Article
- mRNA-expression of ERα, ERβ, and PR in clonal stem cell cultures obtained from human endometrial biopsies.TheScientificWorldJournal · 2011Article
- Tinkering with transcription factors uncovers plasticity of somatic cells.Genes & cancer · 2010Article
- Endometrial stem/progenitor cells: the first 10 years.Human reproduction updateReview
- Expression of pluripotency stem cell markers in endometrial hyperplasia.Women's health (London, England)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The human endometrium is a tissue with remarkable plasticity and regenerative capacity. Additionally, endometrial cells can be retrieved using minimally invasive procedures, which makes them an ideal source for reprogramming into a pluripotent state. Endometrial cells were obtained from donors in their fifth decade and reprogrammed into induced pluripotent stem (iPS) cells using retroviral transduction with SOX2, OCT4, KLF4, and MYC. The human endometrial cells displayed accelerated expression of endogenous NANOG and OCT4 during reprogramming compared with neonatal skin fibroblasts. As a result, iPS cell colonies that could be subcultured and propagated were established as early as 12 d after transduction rather than the usually reported 3-4 wk for other cell types. After 3 wk of reprogramming, the human endometrial cells also yielded significantly higher numbers of iPS colonies in comparison with the neonatal skin fibroblasts. Although the efficiency of iPS colony formation varied depending on the donor, the basal level of endogenous expression of the defined factors was positively correlated with reprogramming efficiency. The reprogramming resulted in an average colony-forming efficiency of 0.49 ± 0.10%, with a range from 0.31-0.66%, compared with the neonatal skin fibroblasts, resulting in an average efficiency of 0.03 ± 0.00% per transduction, with a range from 0.02-0.03%. Our studies show that the human endometrium expresses elevated levels of pluripotent factors, which with additional defined factors, results in significantly more efficient and accelerated generation of induced pluripotent stem cells compared with conventional somatic cells.
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