Evidence map›Paper›PMID 21208921›Full record

ArticleThe Journal of infectious diseases2011

Perspective: alpha-bugs, their microbial partners, and the link to colon cancer.

Cynthia L Sears, Drew M Pardoll

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. The role of gut microbiota and its metabolites in preventing oncogenesis.Frontiers in cell and developmental biology · 2026
    Review
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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cynthia L SearsDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. csears@jhmi.edu
Drew M Pardoll

Funding

PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXINR01DK045496 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 1993 to 2010
$3.6M
Enterotoxigenic Bacteroides fragilis: A bacterial promoter of colon oncogenesisR01CA151393 · NCI · JOHNS HOPKINS UNIVERSITY · PI PARDOLL, DREW M., SEARS, CYNTHIA · 2010 to 2014
$2.7M
Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilisR01DK080817 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 2008 to 2012
$1.7M
Mechanisms of TH17 Inflammation-Induced Colon CarcihogenesisR01CA151325 · NCI · JOHNS HOPKINS UNIVERSITY · PI PARDOLL, DREW M., SEARS, CYNTHIA · 2010 to 2014
$1.6M
Pathogen of Enterotoxigenic Bacteriodes Fragilis InfectR01DK059655 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 2001 to 2003
$757k
NCI NIH HHS R01 CA151325NCI NIH HHS R01 CA151393NIDDK NIH HHS R01 DK045496NIDDK NIH HHS R01 DK059655NIDDK NIH HHS R01 DK080817NIDDK NIH HHS R01 DK45496
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BacteriaColonColonic NeoplasmsHumans

Identifiers

PMID21208921
PMCPMC3071114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.