ArticleUltrasound in medicine & biology2011
Effects of attenuation and thrombus age on the success of ultrasound and microbubble-mediated thrombus dissolution.
Article in Ultrasound in medicine & biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Beyond silence: evolving ultrasound strategies in the battle against cardiovascular thrombotic challenges.Journal of thrombosis and thrombolysis · 2024Review
- Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results in Selective Bioactivation of the Risk Area.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024Article
- Acoustic Detection of Retained Perfluoropropane Droplets Within the Developing Myocardial Infarct Zone.Ultrasound in medicine & biology · 2022Article
- Sono-assisted-thrombolysis by three-dimensional diagnostic ultrasound improves epicardial recanalization and microvascular perfusion in acute myocardial infarction.Quantitative imaging in medicine and surgery · 2022Article
- Contrast Ultrasound, Sonothrombolysis and Sonoperfusion in Cardiovascular Disease: Shifting to Theragnostic Clinical Trials.JACC. Cardiovascular imaging · 2022Review
- The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication.Journal of biomedical science · 2021Review
- Examining the Influence of Low-Dose Tissue Plasminogen Activator on Microbubble-Mediated Forward-Viewing Intravascular Sonothrombolysis.Ultrasound in medicine & biology · 2020Article
- Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers.Sensors (Basel, Switzerland) · 2020Review
- The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro.Physics in medicine and biology · 2019Article
- Guided longer pulses from a diagnostic ultrasound and intraclot microbubble enhanced catheter-directed thrombolysis in vivo.Journal of thrombosis and thrombolysis · 2017Article
- Sonothrombolysis.Advances in experimental medicine and biology · 2016Review
- Improved sonothrombolysis from a modified diagnostic transducer delivering impulses containing a longer pulse duration.Ultrasound in medicine & biology · 2014Article
- Prevention of arteriovenous shunt occlusion using microbubble and ultrasound mediated thromboprophylaxis.Journal of the American Heart Association · 2014Article
- Improving ultrasound gene transfection efficiency by controlling ultrasound excitation of microbubbles.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Clot retraction affects the extent of ultrasound-enhanced thrombolysis in an ex vivo porcine thrombosis model.Ultrasound in medicine & biology · 2013Article
- Ultrasound-mediated drug delivery for cardiovascular disease.Expert opinion on drug delivery · 2013Review
- Microbubble mediated thrombus dissolution with diagnostic ultrasound for the treatment of chronic venous thrombi.PloS one · 2012Article
- Development of Ultrasound Microbubbles and Phase Shift Microbubbles in Theranostics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The purpose of this study was to examine the effects of applied mechanical index, incident angle, attenuation and thrombus age on the ability of 2-D vs. 3-D diagnostic ultrasound and microbubbles to dissolve thrombi. A total of 180 occlusive porcine arterial thrombi of varying age (3 or 6 h) were examined in a flow system. A tissue-mimicking phantom of varying thickness (5 to 10 cm) was placed over the thrombosed vessel and the 2-D or 3-D diagnostic transducer aligned with the thrombosed vessel using a positioning system. Diluted lipid-encapsulated microbubbles were infused during ultrasound application. Percent thrombus dissolution (%TD) was calculated by comparison of clot mass before and after treatment. Both 2-D and 3-D-guided ultrasound increased %TD compared with microbubbles alone, but %TD achieved with 6-h-old thrombi was significantly less than 3-h-old thrombi. Thrombus dissolution was achieved at 10 cm tissue-mimicking depths, even without inertial cavitation. In conclusion, diagnostic 2-D or 3-D ultrasound can dissolve thrombi with intravenous nontargeted microbubbles, even at tissue attenuation distances of up to 10 cm. This treatment modality is less effective, however, for older aged thrombi.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.