Evidence map›Paper›PMID 21208526›Full record

ArticleRedox report : communications in free radical research2010

Direct reaction of taurine with malondialdehyde: evidence for taurine as a scavenger of reactive carbonyl species.

Guolin Li, Ting Tang, Mijun Peng, Hong He, Dazhong Yin

Open access · bronzeAbstract read
In one paragraph

Article in Redox report : communications in free radical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Review
  5. Black Phosphorus/MnOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Guolin LiThe Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, P.R. China.
Ting Tang
Mijun Peng
Hong He
Dazhong Yin
Hunan Normal University · CNChangsha Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Though taurine has been reported very useful in preventing oxidative stress and various age-related diseases, the detailed biochemical mechanism of its biological functions is not well understood. Direct reaction of malondialdehyde (MDA) with taurine was studied using spectrofluorometry, spectrophotometry and liquid chromatography online with mass spectrometry (LC/MS). The results indicated that taurine reacted readily with MDA at supraphysiological conditions to yield mainly two products: a fluorescent 1,4-dihydropyridine and non-fluorescent enaminal derivatives. Taurine also significantly inhibited the formation of lipofuscin-like fluorescence induced by MDA-modified bovine serum albumin. These findings suggested that taurine effectively reduces carbonyl stress due to the amino group in its molecular structure, and we propose that it should be the mechanism related with the pathophysiological functions of taurine in the biological system.

Indexed as

AnimalsCattleChromatography, LiquidMalondialdehydeMass SpectrometrySerum Albumin, BovineTaurineMalondialdehydeSerum Albumin, BovineTaurine

Identifiers

PMID21208526
PMCPMC7067324
OpenAlexW2062650682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.