ArticleBiology of sex differences2010
Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues.
Article in Biology of sex differences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- An update on the role of sex hormones in the function of the cardiorenal mitochondria.Biochemical Society transactions · 2024Review
- Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy.Microorganisms · 2023Review
- Sex-Related Effects on Cardiac Development and Disease.Journal of cardiovascular development and disease · 2022Review
- Oestrogenic Regulation of Mitochondrial Dynamics.International journal of molecular sciences · 2022Review
- Estrogen and Cardiovascular Health.Frontiers in cardiovascular medicine · 2022Article
- Role of Biological Sex in the Cardiovascular-Gut Microbiome Axis.Frontiers in cardiovascular medicine · 2021Review
- Estrogen-related mechanisms in sex differences of hypertension and target organ damage.Biology of sex differences · 2020Review
- Sex, Gender, and Sex Hormones in Pulmonary Hypertension and Right Ventricular Failure.Comprehensive Physiology · 2019Review
- The Zebrafish (International journal of molecular sciences · 2019Article
- Assessment of Bones Deficient in Fibrillin-1 Microfibrils Reveals Pronounced Sex Differences.International journal of molecular sciences · 2019Article
- Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overload.Biology of sex differences · 2019Article
- Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase.Journal of cellular and molecular medicine · 2017Article
- Progesterone Protects Against Bisphenol A-Induced Arrhythmias in Female Rat Cardiac Myocytes via Rapid Signaling.Endocrinology · 2017Article
- Single acute stress-induced progesterone and ovariectomy alter cardiomyocyte contractile function in female rats.Croatian medical journal · 2014Article
- Estrogen regulation of protein expression and signaling pathways in the heart.Biology of sex differences · 2014Article
- Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice.Genes & nutrition · 2013Article
- Sex-deparities in cardiac electrophysiology: L-type Ca2+ current and the Na+-Ca2+ exchanger go hand in hand.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough circulating levels of sexual hormones in elderly men and women are low and quite similar, the adaptation of the elderly heart to stress differs between the sexes. We have hypothesized that the effects of sexual hormones in the heart may differ in men and women. Here, we assessed whether 17β-oestradiol regulates gene expression in the human heart in a sex-dependent manner. We selected the progesterone receptor as a well studied 17β-oestradiol target that may be pathologically linked to cardiac remodelling.
methodsIn order to assess the ex vivo effects of 17β-oestradiol in intact human cardiac tissues, we developed a 24-h model for the culture of human atrial myocardium. We verified tissue viability after 24 h in culture with two standard assays to determine the degree of apoptosis and metabolic activity of cardiac tissues. Progesterone receptor mRNA and protein level were measured after 24-h treatment of tissues with 17β-oestradiol. Statistical analysis was performed by the Mann-Whitney U test and two-way ANOVA.
resultsWe established a tissue culture model that allows for the study of viable human cardiac tissue over a 24-h period. After 24 h, cultured cardiac tissues revealed low apoptosis, retained their metabolic activity and, therefore, remained viable. Treatment with 17β-oestradiol led to an induction of the progesterone receptor mRNA level in female (P = 0.001) but not in male tissues. Similarly, there was an increase in the level of progesterone receptor protein in female tissues (P = 0.03), while a decreasing trend was observed in male tissues (P = 0.079) exposed to 17β-oestradiol.
conclusionsOur novel finding may offer a molecular explanation for the sex-specific differences observed in cardiac remodelling. The culture model we established for human cardiac tissue will facilitate the study of cellular processes in health and disease and will be of use for pharmacological testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.